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Plenity vs. Wegovy

Plenity is an FDA-cleared medical device in pill form that's used for weight loss. It's taken by mouth along with a healthy diet and regular exercise through a weight management program that's supervised by a healthcare provider. Plenity is made up of natural ingredients (cellulose and citric acid). Since it works directly in your digestive tract, Plenity can help you feel full and eat less. But it might cause side effects like diarrhea, constipation, and bloating. Plenity is not a medication, and it might not be safe for people with stomach issues.

• Weight loss, used in addition to a healthy diet and regular exercise

• Diarrhea (13%)
• Bloating or swelling in the stomach area (12%)
• Common cold symptoms (12%)
• Passing gas (9%)
• Constipation or not having bowel movements often (5-9%)
• Headache (7%)
• Stomach pain (5%)
• Nausea (5%)

In clinical studies, there were no overall differences in the rate of side effects between those using Plenity and those using placebo.

• Trouble swallowing Plenity
• Caution in people with stomach issues
• Not a food substitute

Wegovy (semaglutide) is a glucagon-like peptide-1 (GLP-1) receptor agonist. It comes in prefilled pens you use to inject the medication under the skin once a week. Wegovy (semaglutide) also comes as tablets that are swallowed once a day. This medication is approved for weight loss in some people. It can help lower the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease. The pens are also approved for certain adults with a liver problem called metabolic dysfunction-associated steatohepatitis (MASH). The medication works best when taken with a lower-calorie diet and regular exercise. Side effects include nausea, diarrhea, and stomach pain.

Injectable pens:

• Weight loss and long-term weight management in:

  • People ages 12 years and older who are considered obese
  • Adults considered overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes, high cholesterol)

• Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

• Metabolic dysfunction-associated steatohepatitis (MASH) in adults with moderate-to-advanced liver scarring, but not cirrhosis

Tablets:

• Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition
• Lowering the risk of heart attack, stroke, and death due to heart problems in adults with a larger body size and heart disease

• Nausea (44%)
• Diarrhea (30%)
• Vomiting (24%)
• Constipation (24%)
• Stomach pain (20%)
• Headache (14%)
• Tiredness (11%)

• Possible risk for thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Kidney damage
• Allergic reactions
• Eye problems in people with Type 2 diabetes (diabetic retinopathy)
• Faster heart rate
• Lung problems during general anesthesia or deep sedation