Key takeaways
Oxybutynin ER (Ditropan XL) and Tolterodine (Detrol) are both used to treat overactive bladder (OAB), but they have some differences. Both Oxybutynin ER and tolterodine are available in both short-acting and long-acting forms. Oxybutynin ER can be taken as a tablet, patch, or gel, whereas Tolterodine is only available as an oral medication. Oxybutynin ER tends to cause more dry mouth compared to Tolterodine, but some studies suggest it might be more effective in controlling OAB symptoms. Tolterodine is less likely to cause dry mouth but can still lead to dizziness and constipation. Both medications can cause drowsiness and should be used carefully in older adults due to the risk of falls. If you have liver or kidney problems, your provider might adjust your dose of Tolterodine, but Oxybutynin ER is not recommended for people with certain stomach or urinary conditions.
