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Methylprednisolone vs. Prednisolone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Methylprednisolone (Medrol) and prednisolone sodium phosphate (Pediapred) are both corticosteroids used to treat conditions related to an overactive immune system or inflammation, such as rheumatoid arthritis and lupus. They work by reducing inflammation and calming the immune response. However, there are some differences between the two medications. Methylprednisolone is available in both oral and injectable forms, while prednisolone is only available as an oral solution or tablet. The typical starting dose for methylprednisolone ranges from 4 mg to 48 mg per day, whereas prednisolone's starting dose ranges from 5 mg to 60 mg per day. Both medications are available as a lower-cost generic. Common side effects for both include trouble sleeping, mood changes, and stomach pain, and can also cause high blood sugar with long-term use. Both medications have a number of interactions, so be sure your prescriber and pharmacist have a complete list of your medications.

Methylprednisolone

(Medrol)

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Prednisolone

 

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Summary for Methylprednisolone

Prescription only

Methylprednisolone (Medrol) is a steroid medication used to treat different medical conditions with an overactive immune system. It's typically available by prescription as tablets. And it sometimes comes in a dose pack, which helps you organize the tablets into specific days and times. If you use methylprednisolone (Medrol) for a long time, it might cause certain side effects, such as weight gain, skin thinning, and high blood sugar.

Indications for Methylprednisolone

Methylprednisolone (Medrol) is used for many different medical conditions, including:

Pros and Cons for Methylprednisolone

Pros

  • Available as a lower-cost, generic medication
  • Works well to treat many different conditions involving the immune system
  • Also available in an easy-to-follow dose pack that organizes tablets into specific days and times

Cons

  • Long-term use might weaken your bones and cause high blood sugar
  • Can cause side effects like upset stomach, mood changes, and sleep problems
  • Need to slowly lower your dose if you take it for a long time

Common Side Effects for Methylprednisolone

  • Swelling
  • Muscle weakness
  • Stomach pain
  • Bloating
  • Increased appetite
  • Trouble sleeping
  • Weight gain
  • Dizziness

Warnings for Methylprednisolone

  • New or worsened infection
  • Mood and behavior changes
  • Reduced adrenal gland function
  • Changes in heart and kidney function
  • Stomach problems
  • Bone problems with long-term use
  • Eye problems with long-term use
  • High blood sugar

Summary for Prednisolone

Prescription only

Oral prednisolone is a corticosteroid. It's taken by mouth to treat health conditions related to an overactive immune system or inflammation, such as rheumatoid arthritis and lupus, in adults and children. Your healthcare team will determine your dose based on what medical condition you have. Some common short-term side effects of prednisolone include trouble sleeping and mood changes. And if you take this medication for a longer period of time, you're more likely to experience long-term side effects, like weight gain and weakened immune system. If you need to stop prednisolone, your healthcare team might need to taper down your dosage slowly to avoid withdrawal symptoms.

Indications for Prednisolone

This medication is used for many different conditions. Generally, it's used for autoimmune disorders, conditions related to swelling, or cancer. Some examples include:

Pros and Cons for Prednisolone

Pros

  • Works well to treat many different conditions involving the immune system
  • Dose can be adjusted based on your response
  • Available as a lower-cost generic
  • Available as a liquid that might be easier for children

Cons

  • Can cause side effects like upset stomach, mood changes, and sleep problems
  • Long-term use can cause problems with skin, bone, and eye health.
  • Can raise your risk for infections
  • Need to taper your dose before stopping

Common Side Effects for Prednisolone

  • Swelling (e.g., puffiness in the face, hands, or feet)
  • High blood pressure
  • High blood sugar
  • Muscle weakness
  • Stomach pain
  • Insomnia (trouble sleeping)
  • Changes in your mood
  • Headache
  • Acne
  • Weight gain and greater appetite

Warnings for Prednisolone

  • Greater risk of infections
  • Changes in heart and kidney function
  • Bone problems with long-term use
  • Reduced adrenal gland function
  • Eye Problems
  • Mood and behavior changes
  • Stomach problems

Prices with our coupons for Methylprednisolone vs. Prednisolone

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Methylprednisolone1 dose pack / 21 tablets of 4mg
$10.19$33.49
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Prednisolone Sodium Phosphate50 ml / 15mg/5ml
$14.79$24.06
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