Key takeaways
Loxapine (generic, formerly sold as Loxitane) and aripiprazole (Abilify) are both antipsychotic medications, but they belong to different classes. Loxapine is a first-generation (typical) antipsychotic, while aripiprazole is an atypical antipsychotic. Loxapine is primarily used to treat schizophrenia and is available only in generic form. It can cause more movement-related side effects, such as shakiness and stiffness, compared to aripiprazole. Aripiprazole, on the other hand, is used to treat a wider range of conditions, including schizophrenia, bipolar I disorder, depression (as an add-on treatment), Tourette syndrome, and irritability associated with autism. It is available in various forms, including tablets, oral solutions, and orally disintegrating tablets. Aripiprazole is less likely to cause weight gain and movement problems than loxapine but can still lead to issues like high blood sugar and cholesterol. Both medications can cause drowsiness and have serious side effects like neuroleptic malignant syndrome and low white blood cell count. However, aripiprazole also carries risks of impulse control problems and suicidal thoughts.
