Key takeaways
Hyoscyamine (Levsin, Hyosyne, Symax, Oscimin, NuLev) and Viberzi (eluxadoline) are both medications used to treat irritable bowel syndrome (IBS), but they belong to different medication classes. Hyoscyamine is an anticholinergic medication that helps with symptoms like stomach cramps and overactive bladder by blocking acetylcholine, while Viberzi is an opioid receptor agonist/antagonist that targets opioid receptors to relieve IBS with diarrhea (IBS-D) symptoms. Hyoscyamine is available in various oral forms, such as tablets and liquid, and is taken multiple times a day, whereas Viberzi is an oral tablet taken twice daily with food. Hyoscyamine is available as a lower-cost generic, while Viberzi is only available as a brand-name medication. Additionally, Viberzi is a controlled substance due to its potential for misuse and dependence. Common side effects of hyoscyamine include dry mouth and dizziness, while Viberzi can cause constipation and nausea. Additionally, Viberzi carries a risk of pancreatitis, especially in people without a gallbladder and those who consume excessive amounts of alcohol.
