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Janumet vs. Janumet XR

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Janumet

(sitagliptin / metformin)

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Janumet XR

(sitagliptin / metformin)

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Summary for Janumet

Prescription only

Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

Indications for Janumet

Pros and Cons for Janumet

Pros

Cons

  • Must take twice a day with meals
  • Only available as a fixed dose, so can be hard to make dose adjustments
  • Not a good option for people with severe kidney problems
  • Not approved for people with Type 1 diabetes

Common Side Effects for Janumet

Warnings for Janumet

  • Lactic acidosis
  • Inflammation of the pancreas (pancreatitis)
  • Risk of heart failure
  • Sudden kidney problems
  • Low vitamin B12 levels
  • Low blood sugar (hypoglycemia) when taken with certain diabetes medications
  • Joint pain
  • Severe skin reaction
  • Serious allergic reactions

Summary for Janumet XR

Prescription only

Janumet XR (sitagliptin / metformin) is a combination medication for adults with Type 2 diabetes. It contains two different diabetes medications that help improve blood sugar control. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. Janumet XR is an extended-release tablet that you take once a day. To get the most out of the medication, take it along with a balanced diet and regular exercise. Some side effects are diarrhea, upper respiratory tract infection, and headache. Currently, this medication is brand name only; there's no generic version available.

Indications for Janumet XR

Pros and Cons for Janumet XR

Pros

Cons

  • Only available as a fixed dose, so can be hard to make dose adjustments
  • Not a good option for people with severe kidney problems
  • Not approved for people with Type 1 diabetes

Common Side Effects for Janumet XR

Warnings for Janumet XR

  • Lactic acidosis
  • Inflammation of the pancreas (pancreatitis)
  • Risk of heart failure
  • Sudden kidney problems
  • Low vitamin B12 levels
  • Low blood sugar (hypoglycemia) when taken with certain diabetes medications
  • Joint pain
  • Severe skin reaction
  • Serious allergic reactions

Prices with our coupons for Janumet vs. Janumet XR

Price Card Drug Icon
Janumet60 tablets / 50mg/1000mg
$331.56$428.99
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Price Card Drug Icon
Janumet XR180 tablets / 50mg/1000mg
$965.73$1,484.76
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