Key takeaways
Hyzaar (losartan/hydrochlorothiazide) and metoprolol/hydrochlorothiazide (Lopressor HCT) are both combination medications used to lower blood pressure, but they work in different ways. Hyzaar combines an angiotensin II receptor blocker (losartan) with a thiazide diuretic (hydrochlorothiazide), while metoprolol/hydrochlorothiazide combines a beta blocker (metoprolol tartrate) with the same thiazide diuretic. Hyzaar is typically taken once daily, whereas metoprolol/hydrochlorothiazide can be taken once or twice daily with food. Hyzaar is not recommended for use during pregnancy due to risks to the unborn baby, while metoprolol/hydrochlorothiazide should be used cautiously in people with certain heart conditions and breathing problems. Both medications can cause dizziness and increased urination, but metoprolol/hydrochlorothiazide also has a risk of masking symptoms of low blood sugar and overactive thyroid. Additionally, Hyzaar is available in generic form, while the brand name for metoprolol/hydrochlorothiazide, Lopressor HCT, is no longer available.
