Key takeaways
Endometrin (progesterone) and Prometrium (progesterone) are both used to address hormone-related issues, but they have different applications and forms. Endometrin is a vaginal insert or suppository primarily used in fertility treatments to prepare the uterus for pregnancy. It must be inserted 2 to 3 times a day and is only available as a brand medication, which can be expensive. On the other hand, Prometrium is available as an oral capsule and an injection, and it helps regulate menstrual cycles, manage abnormal uterine bleeding, and protect the uterus from damage in postmenopausal women using estrogen replacement therapy. Prometrium capsules are taken once a day, often at bedtime, and are available in a lower-cost generic form. However, Prometrium capsules contain peanut oil, making them unsuitable for those with peanut allergies. Both medications can cause side effects like stomach bloating, but Prometrium is more likely to cause dizziness and drowsiness. Serious risks of both these medications include blood clots, strokes, and heart attacks.
