Key takeaways
Estradiol gel (EstroGel) and Prefest (estradiol/norgestimate) are both medications used to relieve menopausal symptoms like hot flashes and vaginal dryness. However, they have some important differences. Estradiol gel is an estrogen replacement therapy applied topically, while Prefest is a combination of estrogen and progestin taken by mouth. Estradiol gel is available in both brand-name and generic forms, whereas Prefest is only available as a brand-name medication. Estradiol gel is applied once daily to the arm, while Prefest involves alternating between two different tablets every three days. Common side effects of estradiol gel include headaches and breast pain, while Prefest may cause headaches, cold-like symptoms, and joint pain. Both medications carry risks of serious side effects like blood clots and certain cancers, but Prefest also includes progestin to help protect the uterus.
