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Clobetasol vs. Tacrolimus

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Clobetasol (Clobex, Olux) and tacrolimus (Protopic) are both topical medications used to treat skin conditions, but they belong to different medication classes. Clobetasol is a corticosteroid used for conditions like psoriasis and eczema, while tacrolimus is an immunosuppressant specifically approved for moderate-to-severe eczema. Clobetasol is a super potent steroid available in various forms like cream, shampoo, and spray, and is typically used for up to 2 weeks (4 weeks for shampoo). Tacrolimus, on the other hand, is a non-steroid ointment available in two strengths and can be used for up to 6 weeks or longer under a prescriber's guidance. Clobetasol is available as a lower-cost generic and is not recommended for use on the face, armpits, or groin, whereas tacrolimus can be applied to these areas. Common side effects of clobetasol include burning and skin irritation, while tacrolimus may cause burning, itching, and flu-like symptoms. Clobetasol can lead to skin thinning and high blood sugar if used long-term, while tacrolimus carries a risk of skin infections and increased sensitivity to sunlight.

Clobetasol

 

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Tacrolimus

(Protopic)

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Summary for Clobetasol

Prescription only

Clobetasol is a super potent (very strong) corticosteroid that's applied to the skin. It helps relieve skin inflammation and irritation from moderate-to-severe skin problems, like psoriasis. Clobetasol is available in many different formulations. This includes a cream, ointment, shampoo, topical solution, and foam. Most formulations are for people 12 years and older. But others, like the shampoo and lotion, are for adults only. Some side effects include burning, stinging, and irritation where it's applied. Clobetasol has both brand-name and generic options.

Indications for Clobetasol

  • Skin rashes and itchy skin - all topical forms except shampoo
  • Plaque psoriasis not on the scalp - all topical forms except shampoo
  • Moderate-to-severe scalp psoriasis - shampoo and certain foams only

Pros and Cons for Clobetasol

Pros

  • One of the most potent (strongest) topical steroids
  • Applied directly to the affected area(s) of skin
  • Many formulations to choose from, such as ointment, cream, and spray
  • Works well for managing psoriasis symptoms

Cons

  • For short-term use only (usually no more than 2 weeks at a time) to prevent skin thinning and other problems
  • Not safe to use on the face, armpits, or groin
  • Some formulations are only for adults (e.g., shampoo, lotion, spray)
  • Not known if safe to use while pregnant or breastfeeding

Common Side Effects for Clobetasol

  • Burning
  • Stinging
  • Skin irritation
  • Itching

Warnings for Clobetasol

  • More skin reactions with longer use and coverings
  • Changes in stress hormone levels
  • Topical steroid withdrawal
  • Higher risk of cataracts and glaucoma
  • Treat any skin infections appropriately
  • Flammable (clobetasol foam, solution, and spray only)

Summary for Tacrolimus

Prescription only

Tacrolimus (Protopic) is a prescription non-steroid ointment used short-term on the skin to treat moderate-to-severe eczema (atopic dermatitis). It's a calcineurin inhibitor that helps lower the immune system’s response so it doesn’t cause inflammation and make eczema worse. Tacrolimus (Protopic) is approved for both adults and children ages 2 years and older who don't have a weakened immune system. It comes as both a brand-name and generic ointment that you apply to the affected area twice daily. Common side effects include stinging, itching, and a burning sensation at the application site.

Indications for Tacrolimus

  • Moderate-to-severe eczema in adults and children ages 2 years and older

Pros and Cons for Tacrolimus

Pros

  • Non-steroid option for treating eczema
  • Usually starts to work as early as 1 week
  • Can be used in both adults and children
  • Can be applied to the face, neck, groin, around the eyes, or in skin folds

Cons

  • Not a first-choice medication for treating eczema
  • Typically only used short term
  • Can cause burning and stinging where you apply it
  • Unknown if safe during pregnancy or while breastfeeding

Common Side Effects for Tacrolimus

Adults:

  • Skin burning (up to 58%)
  • Itchiness (up to 46%)
  • Flu-like symptoms (up to 31%)
  • Skin redness (up to 28%)
  • Headache (up to 20%)

Children:

  • Skin burning (up to 43%)
  • Itchiness (up to 41%)
  • Flu-like symptoms (up to 34%)

Warnings for Tacrolimus

  • Long-term use and risk of cancer
  • Risk of infection
  • Swollen lymph nodes
  • Sun exposure
  • Sudden kidney failure

Prices with our coupons for Clobetasol vs. Tacrolimus

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Clobetasol1 tube / 60g of 0.05%
$19.32$398.46
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Tacrolimus1 tube / 60g of 0.1%
$63.96$465.03
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