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Clobetasol vs. Hydrocortisone

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Clobetasol (Clobex, Olux) and hydrocortisone (Locoid, Pandel) are both topical corticosteroids used to treat skin conditions like eczema and psoriasis. However, they differ in potency and availability. Clobetasol is a super potent steroid, while hydrocortisone is less potent and available over-the-counter in lower strengths. Clobetasol is typically prescribed for more severe skin issues and is available in various forms like cream, shampoo, and spray, but should not be used for more than 2 to 4 weeks due to potential side effects like skin thinning. Hydrocortisone, on the other hand, is available in creams, ointments, and lotions, and can be used more frequently, up to 4 times daily, but also for short-term use. Clobetasol is generally for adults and children over 12, while hydrocortisone can be used by children as young as 2 years old in some formulations. Both medications can cause side effects like burning and itching, but clobetasol has a higher risk of serious side effects due to its potency. Always consult your provider before using these medications, especially if you are pregnant or breastfeeding.

Clobetasol

 

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topical hydrocortisone

 

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Summary for Clobetasol

Prescription only

Clobetasol is a super potent (very strong) corticosteroid that's applied to the skin. It helps relieve skin inflammation and irritation from moderate-to-severe skin problems, like psoriasis. Clobetasol is available in many different formulations. This includes a cream, ointment, shampoo, topical solution, and foam. Most formulations are for people 12 years and older. But others, like the shampoo and lotion, are for adults only. Some side effects include burning, stinging, and irritation where it's applied. Clobetasol has both brand-name and generic options.

Indications for Clobetasol

  • Skin rashes and itchy skin - all topical forms except shampoo
  • Plaque psoriasis not on the scalp - all topical forms except shampoo
  • Moderate-to-severe scalp psoriasis - shampoo and certain foams only

Pros and Cons for Clobetasol

Pros

  • One of the most potent (strongest) topical steroids
  • Applied directly to the affected area(s) of skin
  • Many formulations to choose from, such as ointment, cream, and spray
  • Works well for managing psoriasis symptoms

Cons

  • For short-term use only (usually no more than 2 weeks at a time) to prevent skin thinning and other problems
  • Not safe to use on the face, armpits, or groin
  • Some formulations are only for adults (e.g., shampoo, lotion, spray)
  • Not known if safe to use while pregnant or breastfeeding

Common Side Effects for Clobetasol

  • Burning
  • Stinging
  • Skin irritation
  • Itching

Warnings for Clobetasol

  • More skin reactions with longer use and coverings
  • Changes in stress hormone levels
  • Topical steroid withdrawal
  • Higher risk of cataracts and glaucoma
  • Treat any skin infections appropriately
  • Flammable (clobetasol foam, solution, and spray only)

Summary for Hydrocortisone

Prescription or over-the-counter

Topical hydrocortisone is a steroid medication used to treat different skin conditions, such as eczema. It's available in many different formulations, including cream, ointment, lotion, and solution. Some strengths are found over the counter (e.g., hydrocortisone 1%), while you need a prescription for others (e.g., hydrocortisone 2.5%). In general, most people experience few to no side effects while using topical hydrocortisone as directed. Rarely, topical hydrocortisone might cause topical steroid withdrawal (TSW). Watch out for skin rashes and irritations that get worse after stopping this medication.

Indications for Hydrocortisone

Short-term relief of skin irritations (e.g., itching) due to:

  • Skin inflammation
  • Skin rashes
  • Eczema
  • Psoriasis
  • Insect bites
  • Poison ivy or oak
  • Skin allergies
  • Dry scalp
  • Genital or rectal irritation

Pros and Cons for Hydrocortisone

Pros

  • Available as a lower-cost, generic medication
  • Available over the counter
  • Many formulations to choose from, such as ointment, cream, and solution

Cons

  • Short-term use only, otherwise it might cause skin thinning and high blood sugar
  • Applied multiple times a day
  • Might affect your body's ability to fight off infections

Common Side Effects for Hydrocortisone

  • Burning
  • Itching
  • Skin irritation
  • Dry skin
  • Inflamed hair follicles

Warnings for Hydrocortisone

  • Hormone problems and withdrawal
  • High blood sugar
  • New or worsened skin infection
  • Skin problems

Prices with our coupons for Clobetasol vs. Hydrocortisone

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Clobetasol1 tube / 60g of 0.05%
$16.01$124.71
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Hydrocortisone1 tube / 30g of 2.5%
$13.53$42.29
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