Key takeaways
Norethindrone acetate (Aygestin) and progesterone (Prometrium) are both used to treat hormone imbalances, but they have some key differences. Norethindrone acetate is used for conditions like absent menstrual periods, abnormal vaginal bleeding, and endometriosis, and is taken orally once a day. Progesterone, on the other hand, is used to regulate menstrual cycles, stop abnormal bleeding, and protect the uterus from damage in postmenopausal women taking estrogen replacement therapy. It is available as an oral capsule or an injection and is taken once a day but only for a certain number of days each month. Norethindrone acetate can cause side effects like breakthrough bleeding and headaches, while progesterone commonly causes dizziness and drowsiness. Additionally, progesterone capsules contain peanut oil, so they are not safe if you have a peanut allergy. Both medications are available in generic forms.
