Nrf2 activators are used to treat health conditions such as relapsing forms of multiple sclerosis and Friedreich's ataxia. Nrf2 activators work by activating the Nrf2 pathway, which helps protect your cells from damage caused by oxidative stress and inflammation. These medications are available in oral forms. Examples include dimethyl fumarate (Tecfidera), diroximel fumarate (Vumerity), and omaveloxolone (Skyclarys).