Estrogen agonist / antagonists are used to treat symptoms of menopause and treat or prevent osteoporosis. They also have other uses, such as managing infertility and treating breast cancer. These medications work by either blocking or activating estrogen receptors in different tissues, which helps to balance the effects of estrogen in your body. They come as oral tablets. Examples include raloxifene (Evista), ospemifene (Osphena), and clomiphene (Clomid). You can discuss with your healthcare team which option might be right for you.