Key takeaways
Gonal-f (follitropin alfa) and Clomid (clomiphene) are both used to treat infertility, but they work in different ways and have different forms. Gonal-f is a gonadotropin that contains follicle-stimulating hormone (FSH) and is given as an injection, while Clomid is a selective estrogen receptor modulator (SERM) taken as a tablet. Gonal-f can treat both male and female infertility, whereas Clomid is only used for female infertility. Gonal-f is typically used for a longer period, up to 35 days for women and many months for men, while Clomid is usually taken for just 5 days during each menstrual cycle. Gonal-f is brand name only and can be very expensive, whereas Clomid is available in a generic form, making it more affordable. Both medications can increase the chance of having twins or more, but Gonal-f requires more frequent monitoring with blood tests and ultrasounds. Common side effects of Gonal-f include headaches and stomach pain, while Clomid often causes hot flashes and stomach pain and bloating.
