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Compare Gonal-F RFF vs. Clomid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Gonal-f (follitropin alfa) and Clomid (clomiphene) are both used to treat infertility, but they work in different ways and have different forms. Gonal-f is a gonadotropin that contains follicle-stimulating hormone (FSH) and is given as an injection, while Clomid is a selective estrogen receptor modulator (SERM) taken as a tablet. Gonal-f can treat both male and female infertility, whereas Clomid is only used for female infertility. Gonal-f is typically used for a longer period, up to 35 days for women and many months for men, while Clomid is usually taken for just 5 days during each menstrual cycle. Gonal-f is brand name only and can be very expensive, whereas Clomid is available in a generic form, making it more affordable. Both medications can increase the chance of having twins or more, but Gonal-f requires more frequent monitoring with blood tests and ultrasounds. Common side effects of Gonal-f include headaches and stomach pain, while Clomid often causes hot flashes and stomach pain and bloating.

  • Gonal-f (follitropin alfa)
    Clomid (clomiphene)
  • Gonal-f (follitropin alfa)
    Clomid (clomiphene)

  • Summary of Gonal-F RFF vs. Clomid

    Summary for Gonadotropin
    Prescription only

    Gonal-f (follitropin alfa) is used to treat infertility in females and males. It's a man-made version of follicle-stimulating hormone (FSH), which plays an important role in follicle and sperm development. Gonal-f (follitropin alfa) is injected under the skin, typically once daily. The dosage of Gonal-f (follitropin alfa) and the duration of treatment can differ from person to person, so follow your fertility specialist's instructions carefully. It's available under different brand names (Gonal-f, Gonal-f RFF, Gonal-f RFF Redi-ject), but not a generic. Some common side effects of this medication include headache and stomach pain.

    Summary for Selective estrogen receptor modulator
    Prescription only

    Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.

  • Indications of Gonal-F RFF vs. Clomid

    Indications for
    •Infertility treatment in females who have trouble ovulating
    •To develop multiple follicles in females going through assisted reproductive technologies (ART), such as in vitro fertilization (IVF)
    •Infertility treatment in males who have hypogonadotropic hypogonadism, a hormone-related condition (Gonal-F only)
    Indications for
    •Female infertility

  • Pros and Cons of Gonal-F RFF vs. Clomid

    Pros and Const for Gonadotropin
    Pros
    •Can inject yourself at home
    •Can be stored at room temperature or in the refrigerator
    •Available as an easy-to-use pre-filled pen (Gonal-f RFF Redi-ject)
    Cons
    •Only available as an injection
    •Multi-dose vials and single-dose vials need to be mixed before injection, which can be inconvenient
    •Brand name only; no generics available
    Pros and Const for Selective estrogen receptor modulator
    Pros
    •Works well for people with polycystic ovary syndrome (PCOS)
    •Usually only taken for 5 days during each cycle
    •Available as a tablet, unlike many alternatives
    Cons
    •Typically only recommended for up to 3 cycles, not a long-term treatment
    •Can cause vision problems in some rare cases
    •Not safe if you have liver problems or certain thyroid problems

  • Common Side Effects of Gonal-F RFF vs. Clomid

    Common Side Effects for

    Females:

    •Ovarian cysts (14%)
    •Headache (up to 13%)
    •Stomach pain (8%)
    •Nausea (7%)
    •Pelvic pain (7%)
    •Ovarian hyperstimulation (7%)
    •Nausea (6%)
    •Passing gas (6%)

    Males

    •Acne (27%)
    •Injection-site pain (11%)
    •Tiredness (10%)
    Common Side Effects for
    •Swollen ovaries (14%)
    •Hot flashes (10%)
    •Stomach pain, discomfort, or bloating (6%)

  • Warnings of Gonal-F RFF vs. Clomid

    Common Side Effects for
    •Swollen ovaries
    •Ovarian hyperstimulation syndrome (OHSS)
    •Lung problems and blood clots
    •Ovarian twisting
    •Getting pregnant with more than one baby
    •Problems during pregnancy
    •Allergic reactions
    Common Side Effects for
    •Vision changes
    •Ovarian hyperstimulation syndrome (OHSS)
    •Possible risk of harm to unborn baby

  • Prices with our coupons for Gonal-F RFF vs. Clomid

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