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Compare Tamoxifen vs. Clomid

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tamoxifen (tamoxifen) and Clomid (clomiphene) are both selective estrogen receptor modulators (SERMs) used to treat different conditions. Tamoxifen is primarily used to treat hormone receptor-positive (HR+) breast cancer and to lower the risk of breast cancer in high-risk females. Clomid, on the other hand, is used to treat female infertility by inducing ovulation. While both medications are taken orally, tamoxifen is usually taken once daily for several years, whereas Clomid is taken once daily for only 5 days during a menstrual cycle. Both medications are available as a lower-cost generic. Common tamoxifen side effects include hot flashes and vaginal discharge, while common Clomid side effects include hot flashes and stomach pain. Alcohol can prevent tamoxifen from working as well. Serious side effects of tamoxifen include an increased risk of uterine cancer and blood clots, whereas Clomid can lead to ovarian hyperstimulation syndrome, a serious condition.

  • Tamoxifen (Nolvadex)
    Clomid (clomiphene)
  • Tamoxifen (Nolvadex)
    Clomid (clomiphene)

  • Summary of Tamoxifen vs. Clomid

    Summary for Selective estrogen receptor modulator (SERM)
    Prescription only

    Tamoxifen (Nolvadex) is a selective estrogen receptor modulator (SERM). It’s used to treat early stage and advanced or metastatic hormone receptor-positive (HR+) breast cancer in males and females. It’s also used to lower the risk for breast cancer in females who have a higher risk for breast cancer. Tamoxifen (Nolvadex) is an oral tablet that's taken by mouth, usually once a day. Common side effects of this medication include hot flashes, vaginal discharge, and swelling in the arms and legs, which might lead to weight gain. Brand name Nolvadex is no longer available.

    Summary for Selective estrogen receptor modulator
    Prescription only

    Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.

  • Indications of Tamoxifen vs. Clomid

    Indications for
    •Metastatic HR+ breast cancer
    •Early-stage HR+ breast cancer after surgery to lower the risk of breast cancer coming back
    •Ductal carcinoma in situ (DCIS) in females after breast surgery and radiation to lower the risk of breast cancer coming back
    •Lowering the risk of breast cancer in females who are considered high risk
    Indications for
    •Female infertility

  • Pros and Cons of Tamoxifen vs. Clomid

    Pros and Const for Selective estrogen receptor modulator (SERM)
    Pros
    •Usually taken once a day
    •Oral tablet is available as a lower-cost generic
    •Might help prevent bone loss (osteoporosis) after menopause
    Cons
    •Might raise your risk for blood clots, uterine cancer, and cataracts
    •Can’t take while pregnant or breastfeeding
    •Usually taken long term (at least 5 years)
    Pros and Const for Selective estrogen receptor modulator
    Pros
    •Works well for people with polycystic ovary syndrome (PCOS)
    •Usually only taken for 5 days during each cycle
    •Available as a tablet, unlike many alternatives
    Cons
    •Typically only recommended for up to 3 cycles, not a long-term treatment
    •Can cause vision problems in some rare cases
    •Not safe if you have liver problems or certain thyroid problems

  • Common Side Effects of Tamoxifen vs. Clomid

    Common Side Effects for
    •Hot flashes (up to 80%)
    •Vaginal discharge (up to 55%)
    •Swelling in the arms and legs (up to 32%)
    •Nausea (up to 26%)
    •Irregular or no monthly bleeding (up to 25%)
    •Vaginal bleeding (up to 23%)
    •Weight loss (23%)
    •Skin changes (19%)
    Common Side Effects for
    •Swollen ovaries (14%)
    •Hot flashes (10%)
    •Stomach pain, discomfort, or bloating (6%)

  • Warnings of Tamoxifen vs. Clomid

    Common Side Effects for
    •Blood clots
    •Changes in the uterus and risk of uterine cancer
    •Eye problems
    •Liver problems
    •High calcium levels in the blood
    •Low platelet count (risk of bleeding)
    •Harm to unborn baby
    Common Side Effects for
    •Vision changes
    •Ovarian hyperstimulation syndrome (OHSS)
    •Possible risk of harm to unborn baby

  • Prices with our coupons for Tamoxifen vs. Clomid

    Learn more about Tamoxifen
    Learn more about Clomid

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