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Linzess
Used for Constipation, Irritable Bowel Syndrome
Used for Constipation, Irritable Bowel Syndrome
Linzess (linaclotide) is approved for people 7 years and older with constipation from irritable bowel syndrome (IBS-C). It's also for adults with long-lasting or chronic constipation from unknown reasons. Children 6 years and older with functional constipation can take this medication as well. Linzess (linaclotide) belongs to a drug class called guanylate cyclase-C agonists. It's a capsule that's taken by mouth once a day. But diarrhea is a common side effect. This medication is currently brand name only; there's no generic version yet.
What is Linzess (linaclotide)?
What is Linzess (linaclotide) used for?
- Irritable bowel syndrome with constipation (IBS-C) in people 7 years and older
- Chronic idiopathic constipation (CIC) in adults
- Functional constipation (FC) in children 6 years and older
How Linzess (linaclotide) works
Linzess (linaclotide) is a guanylate cyclase-C (GC-C) agonist. GC-C is a protein that works in the intestines.
Linzess (linaclotide) turns on the GC-C protein. This raises the amount of fluid in your intestines and speeds up the movement of food through your gut. These actions help you have regular bowel movements and possibly relieve belly pain.
When does Linzess (linaclotide) start working?Time passed since treatment started:
Drug facts
| Common Brands | Linzess |
|---|---|
| Drug Class | GC-C agonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Linzess (linaclotide) essentials
Side effects of Linzess (linaclotide)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
Adults:
- Diarrhea
- Stomach pain
- Having gas
- Bloating and feeling full in the belly
Children:
- Diarrhea
Less Common Side Effects
Adults:
- Headache
- Vomiting
- Indigestion or acid reflux
- Feeling an urgent need to have a bowel movement
- Can't control bowel movements
- Infection (e.g., upper respiratory tract infection, sinus infection)
Children:
- Nausea
- Stomach discomfort
- Dehydration
Linzess (linaclotide) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Severe diarrhea
- Bloody stool or black stool that looks like tar
- Dehydration: confusion, dizziness, exhaustion, fainting, racing heart, dark urine, low amount of urine
When do Linzess (linaclotide) possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Diarrhea
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
More on Linzess (linaclotide) side effects
The following Linzess (linaclotide) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Bleeding from the rectum
bloody, black, or tarry stools
confusion
decreased urination
difficulty swallowing
dizziness
fainting
fast heartbeat
hives or welts, itching, or skin rash or redness
increase in heart rate
lightheadedness
loss of bowel control
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
rapid breathing
shortness of breath
sunken eyes
thirst
tightness in the chest
unusual tiredness or weakness
wrinkled skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Body aches or pain
chills
ear congestion
excess air or gas in the stomach or intestines
full or bloated feeling
headache
loss of voice
passing gas
stuffy or runny nose
Less common
Acid or sour stomach
belching
indigestion
pain or tenderness around the eyes and cheekbones
pressure in the stomach
stomach discomfort or upset
swelling of the abdominal or stomach area
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$730.99
GoodRx discount
$282.90
Pros and cons of Linzess (linaclotide)
Pros
- Only need to take once a day
- Can start to see improvement as early as a week of taking it every day
Cons
- Must take on an empty stomach (30 minutes before a meal)
- Can cause diarrhea
Pharmacist tips for Linzess (linaclotide)
- Take Linzess (linaclotide) on an empty stomach, at least 30 minutes before a meal. It's a good idea to take the medication at about the same time each day. This helps make it a part of your everyday routine so you remember to take your medication.
- If you forget to take a dose of Linzess (linaclotide), skip the missed dose. Wait to take your usual dose the next day. Don't take two doses at the same time. This can cause stomach upset or diarrhea.
- Swallow the Linzess (linaclotide) capsule whole. Don't crush or chew the capsule or the beads inside. Talk to your prescriber if you have trouble swallowing it whole; there might be other options for you.
- Diarrhea is a common side effect of Linzess (linaclotide). It most often starts within the first 2 weeks of starting the medication. Drink plenty of fluids while taking Linzess (linaclotide). This helps prevent dehydration from any diarrhea that you have.
- Stop taking Linzess (linaclotide) and get medical help right away if you have severe diarrhea. Other signs to be aware of include sudden stomach pain and stool that’s bright red or black like tar. Also get medical help right away if you feel dizzy, very tired, faint, or confused. These could be signs of serious dehydration. You should get checked out by a healthcare professional and get treated if needed.
- Keep Linzess (linaclotide) in the original bottle. Don't remove the desiccant packet that's included because it keeps your medication dry. Store Linzess (linaclotide) in a dry place at room temperature.
Tips for taking Linzess (linaclotide) if you have trouble swallowing or have a feeding tube:
- You can open the Linzess (linaclotide) capsule. Then, sprinkle the beads on room-temperature applesauce or bottled water. Follow the instructions carefully, since they're different for applesauce and water. Don't use other foods or liquids since we don't know how they affect the medication.
- Once prepared, swallow the medication right away without chewing the beads. Don’t save any leftover mixtures for later. It might not be safe to take after it's left out for some time.
- If you have a feeding tube, follow the directions to prepare and take Linzess (linaclotide). Open the capsule and pour the beads into a clean container. Mix the beads with room-temperature bottled water. Then, use a syringe to draw up the mixture and put it through the feeding tube as directed.
- If you mix the beads from the capsule with bottled water, you’ll get your full dose of Linzess (linaclotide). This is true even if the beads stay in the cup or if you can't flush them through the feeding tube. The beads won’t disappear in the water. But the medication is on the outside surface of the beads and dissolves into the water.
More on Linzess (linaclotide) tips
Risks and warnings for Linzess (linaclotide)
Linzess (linaclotide) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Not for children under 2 years old because of risk of serious dehydration
Linzess (linaclotide) isn't for children younger than 2 years old because of the risk of serious dehydration. In studies with baby animals, the medication caused severe, deadly dehydration.
Studies show that children over 2 years old aren't likely to have a high risk of life-threatening dehydration with Linzess (linaclotide). But it's not clear how much risk there is for diarrhea and serious dehydration in babies under 2.
Keep Linzess (linaclotide) away from children so they don't take it by accident. If you think a baby has swallowed this medication, call 911 right away. You can also call a poison control center at 1-800-222-1222.
Severe diarrhea
Although it's rare, Linzess (linaclotide) can sometimes cause severe diarrhea. This can lead to dehydration, which can be dangerous.
Be sure to drink lots of fluids while taking Linzess (linaclotide). Stop taking the medication and get medical help right away if you have severe diarrhea, severe stomach pain, bloody stool, or black stool that looks like tar. Also get help if you feel dizzy, very tired, faint, or confused. These could be signs of serious dehydration, which needs to get treated quickly.
Linzess (linaclotide) dosage
The average cost for 30 capsules of 145mcg of Linzess (linaclotide) is $283.09 with a free GoodRx coupon. This is 61.27% off the average retail price of $730.99. 
Capsule
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 145mcg | 30 capsules | $283.09 | $9.44 |
| 290mcg | 30 capsules | $283.01 | $9.43 |
| 72mcg | 30 capsules | $282.90 | $9.43 |
Typical dosage for Linzess (linaclotide)
The dose depends on which type of chronic constipation you have. Take Linzess (linaclotide) on an empty stomach, at least 30 minutes before eating.
-
Irritable bowel syndrome with constipation (IBS-C)
- Adults: The typical dose is 290 mcg by mouth once a day.
- Children 7 years and older: The typical dose is 145 mcg by mouth once a day.
-
Chronic idiopathic constipation (CIC)
- Adults: The typical dose is 72 mcg or 145 mcg by mouth once a day.
-
Functional constipation (FC)
- Children 6 years and older: The typical dose is 72 mcg by mouth once a day.
More on Linzess (linaclotide) dosage
Interactions between Linzess (linaclotide) and other drugs
Linzess (linaclotide) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Linzess (linaclotide). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
How much does Linzess (linaclotide) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Linzess (brand)
$282.90
Linzess (linaclotide) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Linzess (linaclotide) will not be safe for you to take.
- Children younger than 2 years of age
- Known or suspected blockage in the stomach or intestines
What are alternatives to Linzess (linaclotide)?
There are a number of medications that your doctor can prescribe in place of Linzess (linaclotide). Compare a few possible alternatives below.
News about Linzess (linaclotide)
From Diarrhea to the Stomach Flu: 5 Linzess Side Effects You Should Know About
Linzess, or linaclotide, is a medication for chronic constipation. Here are Linzess side effects to know about and how to manage them.
How Much Does Linzess Cost Without Insurance?
A 30-day supply of Linzess can cost over $700 per month without insurance. See what affects the price of Linzess, how insurance covers Linzess, and ways to save.
Linzess Dosages: Your GoodRx Guide
Linzess is used for constipation and other digestive issues. Your Linzess dosage depends on what you’re taking it for and how you’re responding to the medication.
Linzess and Coffee: A Risky Mix or No Big Deal?
Linzess and coffee don’t directly interact. It’s generally safe to consume both. However, coffee consumption can impact the effects of Linzess in some people.
Linzess vs. Miralax: 7 Differences to Consider
Linzess and Miralax both treat constipation, but which one should you take? Here, we’ll review the main differences between Linzess and Miralax.
How Long Does It Take Linzess to Work for Constipation?
For most people, Linzess starts providing constipation relief within 1 week. Learn what to expect when taking Linzess.
Linzess vs. Amitiza for Constipation: The 7 Key Differences You Need to Know
Amitiza and Linzess are prescription medications that treat constipation. Read on to learn how they work differently to fight constipation, dosages, and more.
How Does Linzess Work for Constipation?
Linzess (linaclotide) treats constipation by softening stool, making bowel movements easier. Learn more about how Linzess works with GoodRx.
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Linzess (linaclotide) images
