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Ipratropium / Albuterol Coupon - Ipratropium / Albuterol 3ml of 0.5mg/3mg/3ml vial

ipratropium / albuterol

Generic Duoneb
Used for COPD
Used for COPD

Ipratropium bromide/albuterol sulfate is a combination inhalation solution made up of two different bronchodilators. This combination is used to treat chronic obstructive pulmonary disease (COPD) in adults. It's inhaled through a nebulizer, typically 4 times a day. Side effects of this medication include lung problems, sore throat, and chest pain. The brand name Duoneb has been discontinued, so ipratropium/albuterol solution is only available as a generic.

Last reviewed on September 5, 2023
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$41.560
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$41.56
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What is Ipratropium/albuterol solution?

What is Ipratropium/albuterol solution used for?

How Ipratropium/albuterol solution works

Ipratropium/albuterol solution is a combination of two medications that work together to make it easier to breathe.

Are you looking for information on Combivent Respimat (ipratropium / albuterol) inhaler instead?
When does Ipratropium/albuterol solution start working?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsDuoneb (brand name no longer available)
Drug ClassSAMA / SABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Ipratropium/albuterol solution?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Lung problems (6%)
  • Sore throat (4%)
  • Chest pain (3%)
  • Bronchitis (2%)
  • Diarrhea (2%)
  • Urinary tract infection (2%)

Other Side Effects

  • Pain
  • Indigestion
  • Nausea
  • Leg cramps
  • Pneumonia

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, swelling of your face, lips, or tongue, difficulty breathing
  • Sudden narrowing of your airways: difficulty breathing, wheezing, chest pain or tightness, cough
  • Heart problems: dizziness, fatigue, weakness, tremor, irregular heartbeat, worsening symptoms of heart problem you already have
When do Ipratropium/albuterol solution possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Sore throat
Risk of having a racing heartbeat
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

chills

cough

cough producing mucus

difficulty with breathing

ear congestion

fever

headache

loss of voice

runny nose

sneezing

sore throat

stuffy nose

tightness in the chest

unusual tiredness or weakness

Less common

Bladder pain

bloody or cloudy urine

blurred vision

burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

congestion

diarrhea

difficult, burning, or painful urination

dizziness

fainting

fast, slow, irregular, pounding, or racing heartbeat or pulse

frequent urge to urinate

general feeling of discomfort or illness

hoarseness

increased sputum

joint pain

loss of appetite

lower back or side pain

muscle aches and pains

nausea

nervousness

noisy breathing

pain

pain or tenderness around the eyes and cheekbones

pounding in the ears

shakiness in the legs, arms, hands, or feet

shivering

sweating

swelling

tender, swollen glands in the neck

trembling or shaking of the hands or feet

trouble sleeping

trouble swallowing

voice changes

vomiting

Rare

Skin rash or hives

swelling of the face, lips, eyelids, mouth, or throat

Incidence not known

Chest discomfort

decrease in the frequency of urination

decrease in urine volume

difficulty in passing urine (dribbling)

itching skin

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

pain or discomfort in the arms, jaw, back, or neck

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the skin

welts

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Acid or sour stomach

bad, unusual, or unpleasant (after) taste

belching

change in taste

diarrhea

difficulty with moving

dry mouth

heartburn

indigestion

muscle pain or stiffness

stomach discomfort, upset, or pain

voice changes

Incidence not known

Bigger, dilated, or enlarged pupils (black part of the eye)

blindness

change in near or distance vision

decreased vision

difficulty in focusing eyes

dry throat

eye pain

increased sensitivity of the eyes to light

itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use

lack or loss of strength

noisy breathing

redness of the white part of the eyes or inside of the eyelids

swelling of the eye

swelling or inflammation of the mouth

tearing

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Ipratropium/albuterol solution

thumbs-up

Pros

Starts working within minutes

More convenient to use a combination of two bronchodilators in a single medication

Available as a lower-cost generic

thumbs-down

Cons

Need to use with a nebulizer machine, which can be inconvenient

Takes up to 15 minutes to receive the whole dose

Might not be a good option for those with heart problems

pharmacist-tips

Pharmacist tips for Ipratropium/albuterol solution

pharmacist
  • Carefully read the instructions on how to use ipratropium/albuterol solution with a nebulizer machine to avoid wasting the medication or accidentally hurting yourself (e.g., eye problems, changes in vision). Ask your provider or pharmacist if you have any questions about using the medication.

    • How to set up your nebulizer: When you're ready for your dose, remove one vial from the foil pouch. Twist the cap off the vial to open, and then squeeze the contents into the nebulizer container. Connect the nebulizer to your mouthpiece or face mask, and then connect the nebulizer to the compressor.

      • Sit in a comfortable, upright position during your breathing treatment. Using the mouthpiece or face mask, breathe as calmly, deeply, and evenly as possible until there's no more mist in the nebulizer. This can take up to 15 minutes.

        • Keep the vials of ipratropium/albuterol solution in the original foil pouch and store at room temperature. After opening the pouch, keep any unused vials in the foil pouch to protect them from light.

          • Clean your nebulizer after each time you use it. This helps prevent lung infections that can happen if you use a nebulizer machine that isn't cleaned well.

            • Call your provider if your breathing gets worse or doesn't improve after using ipratropium/albuterol solution. Also contact your provider if you're using ipratropium/albuterol solution more often than usual. These could be signs you need a change in your treatment plan for your breathing problem.

              • Ipratropium/albuterol solution can interact with other medications. Some of these interactions can make your medications not work as well or raise your risk of harmful side effects. Some examples include blood pressure medications (e.g., beta blockers) and antidepressants (e.g., tricyclic antidepressants). Don't start any new medications while taking ipratropium/albuterol solution without asking your provider or pharmacist first whether the combination is safe to take.

                faqs

                Frequently asked questions about Ipratropium/albuterol solution

                How long does ipratropium/albuterol solution take to work, and how long does it last?
                You should notice an improvement in your breathing minutes after you start ipratropium/albuterol solution. And you can expect its maximum benefit about an hour after your dose. Ipratropium/albuterol solution should continue to work for about 5 hours.
                Why are albuterol and ipratropium given together?
                Ipratropium/albuterol solution is made up of two bronchodilators. Both albuterol and ipratropium work differently to open up your airways and improve your breathing. Providers typically prescribe ipratropium/albuterol solution for people when one bronchodilator isn't enough. A study of people who have COPD showed using both medications together works better than using albuterol alone. Please note that though this study compared ipratropium / albuterol inhaler (Combivent) to albuterol inhaler (Ventolin, Proair), the nebulized versions of these medications are expected to have the same results.
                Does ipratropium/albuterol solution have a steroid in it?
                No, ipratropium/albuterol solution doesn't have an inhaled corticosteroid in it. Ipratropium is a short-acting muscarinic antagonist (SAMA), while albuterol is a short-acting beta-agonist (SABA). Both of these medications are bronchodilators. Your provider might prescribe an inhaled steroid for you to use in addition to ipratropium/albuterol solution if you're still having breathing problems while using this medication.
                How do you dispose of ipratropium/albuterol solution?
                You're recommended to safely dispose of expired or leftover vials of ipratropium/albuterol solution by giving it to a drug-take-back programs in your area. Ask your pharmacist if you have trouble finding a take-back site.
                Is ipratropium/albuterol solution safe for infants?
                Ipratropium/albuterol solution hasn't been well-studied in children younger than 18 years of age. This medication is FDA-approved for COPD, which is a condition that typically affects adults. If you suspect your child has a breathing condition, talk to their provider right away. Their provider can help you figure out what might be causing the breathing problem and talk to you about appropriate treatment options.
                What's the difference between ipratropium/albuterol solution and Combivent Respimat?
                Ipratropium/albuterol solution and Combivent Respimat (ipratropium / albuterol) contain the same combination of medications and are both used to treat COPD. The main difference is the type of device that you use to take the medication. Ipratropium/albuterol solution is given using a nebulizer machine that turns the medication solution into a mist that you breathe in continuously for several minutes. But Combivent Respimat is an inhaler that works by using a propellant to spray medication from the inhaler that you breathe into your lungs. Talk with your provider if you have more questions about which medication might be a better option for you.
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                What are the risks and warnings for Ipratropium/albuterol solution?

                Ipratropium/albuterol solution can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Narrowing of your airways (bronchospasm)

                Though extremely rare, ipratropium/albuterol solution can sometimes cause a muscle spasm in your lungs (bronchospasm). This can lead to difficulty breathing, wheezing, cough, and chest discomfort. If you become short of breath after using ipratropium/albuterol solution, get medical attention right away.

                risk-warning

                Heart problems

                • Risk factors: High blood pressure | Heart failure | Heart rate or rhythm problems | Using more ipratropium/albuterol solution than recommended

                  Although rare, ipratropium/albuterol solution can cause changes in your blood pressure and heart rate. If you have high blood pressure or other heart problems, ipratropium/albuterol solution can make it worse, especially if you take the medication more often than instructed. Watch out for worsening signs and symptoms of your heart condition. Tell your provider if you develop dizziness, fatigue, tremor, rapid heartbeat, or weakness while taking ipratropium/albuterol solution.

                  risk-warning

                  Eye problems

                  • Risk factors: History of glaucoma | Exposure of ipratropium/albuterol solution to eyes | Using the nebulizer machine incorrectly

                    Though not common, using ipratropium/albuterol solution can raise the pressure in the eyes. Sometimes, this can cause or worsen glaucoma. Talk to your eye provider before using ipratropium/albuterol solution if you have glaucoma or other eye problems. Also speak with them if you notice any changes to your vision while using the medication. Never spray ipratropium/albuterol solution in your eyes because this could cause eye pain, discomfort, blurry vision, and other vision changes.

                    risk-warning

                    Trouble urinating

                    • Risk factors: Enlarged prostate | Bladder-neck obstruction (blockage)

                      Ipratropium/albuterol solution should be used cautiously in people who have prostate problems, because it can worsen this condition and lead to difficulty urinating. Contact your provider if you notice difficulty urinating while using this medication.

                      risk-warning

                      Severe allergic reactions

                      Severe allergic reactions to ipratropium/albuterol solution are possible, including life-threatening reactions like facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after using ipratropium/albuterol solution.

                      risk-warning

                      Low potassium in the blood

                      • Risk factors: Using ipratropium/albuterol solution too much

                        Ipratropium/albuterol solution can cause the potassium levels in your blood to drop too low if you overdose by using too much ipratropium/albuterol solution. Symptoms of low potassium include tiredness, weakness, muscle cramps or spasms, a racing heart, and a "pins and needles" feeling in your hands and feet. Don't take more ipratropium/albuterol solution than prescribed. If ipratropium/albuterol solution isn't helping your breathing get better, seek medical help right away.

                        dosage

                        Ipratropium/albuterol solution dosage forms

                        The average cost for 30 vials of 3ml of 0.5mg/3mg/3ml of Ipratropium/albuterol solution is $41.95 with a free GoodRx coupon. This is 62.79% off the average retail price of $112.74.
                        vial
                        Vial
                        DosageQuantityPrice as low asPrice per unit
                        3ml of 0.5mg/3mg/3ml1 vial$41.95$41.95

                        Typical dosing for Ipratropium/albuterol solution

                        Each 3 mL vial contains 0.5 mg of ipratropium and 3 mg of albuterol.

                        The typical dose is 1 vial inhaled through the mouth by nebulization 4 times per day, and up to 2 additional doses (for a total maximum of 6 doses per day) if needed for wheezing or shortness of breath.

                        More on Ipratropium/albuterol solution dosage forms

                        interactions

                        Interactions between Ipratropium/albuterol solution and other drugs

                        Ipratropium/albuterol solution may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Ipratropium/albuterol solution. Please note that only the generic name of each medication is listed below.

                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                        Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                        How much does Ipratropium/albuterol solution cost?

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                        contraindications-icon

                        Ipratropium/albuterol solution contraindications

                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Ipratropium/albuterol solution will not be safe for you to take.
                        alternatives

                        What are alternatives to Ipratropium/albuterol solution?

                        There are a number of medications that your doctor can prescribe in place of Ipratropium/albuterol solution. Compare a few possible alternatives below.
                        Ipratropium/albuterol solution
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                        images

                        Ipratropium/albuterol solution images

                        This medicine is Colorless Vial.
                        This medicine is Colorless Vial.
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3ml Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3ml Solution for Inhalation
                        This medicine is Colorless Vial.
                        This medicine is Colorless Vial.
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation
                        This medicine is Colorless Vial.colorless - Ipratropium Bromide / Albuterol Sulfate 0.5mg-3mg / 3mL Solution for Inhalation

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                        References

                        Best studies we found

                        American Lung Association. (2023). How to clean a nebulizer.

                        American Lung Association. (2023). How to use a nebulizer.

                        American Thoracic Society. (2020). Nebulizer breathing treatments at home.

                        View All References (5)

                        Campbell, S. (1999). For COPD a combination of ipratropium bromide and albuterol sulfate is more effective than albuterol base. Archives of Internal Medicine.

                        Hsu, E., et al. (2023). Beta2-agonists. StatPearls.

                        Ritedose Pharmaceuticals, LLC. (2023). Ipratropium bromide and albuterol sulfate solution [package insert]. DailyMed.

                        Sam, C., et al. (2023). Physiology, acetylcholine. StatPearls.

                        U.S. Food and Drug Administration. (2022). Drug disposal: Drug take back locations.

                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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