Atropine (Isopto Atropine) is an eye medication that's used to dilate or widen the pupil (the black part of your eye). It's also used to treat lazy eye. This medication is an anticholinergic that works to make the pupil bigger. Atropine (Isopto Atropine) comes as eye drops and an eye ointment. The usual dosage is to apply the medication to the eye(s) 1 to 2 times daily. It can be used in people 3 months and up according to the eye specialist's instructions. Side effects include temporary eye pain, stinging, eye sensitivity to light, and blurry vision. Atropine (Isopto Atropine) is available as a brand-name and generic medication.
Pupil dilation (e.g., for eye exams) - eye drops and eye ointment
Temporary paralysis of the eye muscle (cycloplegia) - eye drops and eye ointment
Treatment for lazy eye - eye drops only
Atropine (Isopto Atropine) is an anticholinergic medication. When it's placed in the eye, the medication blocks signals that normally make the pupil smaller and focus on objects. This widens (dilates) the pupil. The medication also relaxes the eye muscle that helps you focus on nearby objects, making it harder to see up close.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Symptoms of too much medicine being absorbed into the body
Clumsiness or unsteadiness
confusion or unusual behavior
dryness of skin
fast or irregular heartbeat
flushing or redness of face
seeing, hearing, or feeling things that are not there
skin rash
slurred speech
swollen stomach in infants
thirst or unusual dryness of mouth
unusual drowsiness, tiredness, or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Blurred vision
brief burning or stinging of the eyes
eye irritation not present before use of this medicine
increased sensitivity of eyes to light
swelling of the eyelids
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Eye drops can be used in children 3 months and older
Can be used as an alternative to wearing a patch over the stronger eye for treating lazy eye
Can make your eyes sensitive to light and vision blurry for up to 2 weeks
Might raise your blood pressure
For use during routine eye exams: You'll typically get atropine (Isopto Atropine) placed in the eye(s) at the eye specialist's office during a routine eye exam. After your appointment, consider wearing sunglasses when you go outside since your pupils might still be dilated and your eyes will be sensitive to light. It might be a good idea to have someone drive you to and from your eye appointment.
For use at home for lazy eye: Follow the eye specialist's instructions when you or your child uses atropine (Isopto Atropine) at home for treating lazy eye. This makes sure you use the medication safely. Wash your hands with soap and water before and after you use the medication to prevent it from getting into the mouth.
Atropine (Isopto Atropine) can blur your vision and cause light sensitivity, sometimes lasting a couple weeks. Some people might also feel drowsy after they use this medication. Don't drive a car or operate machinery until you know how this medication affects you.
Don't let the tip of the tube or eye drop bottle touch the eye, eyelid, fingers, or other surfaces. Otherwise, atropine (Isopto Atropine) can get contaminated with germs and cause serious harm to the eye, like infection and vision loss.
If you wear contact lenses, make sure to take them out before you place atropine (Isopto Atropine) into the eye. The eye drops contain a preservative that can damage your lenses. Wait at least 15 minutes after you place the medication in your eye before putting your lenses back in. Check with your eye specialist about using contact lenses during treatment with atropine (Isopto Atropine).
While looking up, pull down your lower eyelid with one hand and hold the eye drop bottle upside down above your eye. Then, squeeze the number of drops you need for your dose.
After you place the drop(s) in your eye, close your eye for 2 to 3 minutes. Press down on the inner corner of your eye near your nose with your finger for a minute to keep the medication in your eye and prevent it from leaking. Wipe away any extra medication from your face with a clean, dry tissue.
If you need to use another eye drop medication with atropine (Isopto Atropine) in the same eye, wait at least 5 minutes so the second eye drop doesn't rinse off the first one.
First, tilt your head back slightly. Then, pull down your lower eyelid with one hand and hold the tube of ointment with the other. Place a half-inch strip of ointment in the space between your eyelid and eye.
After you place the ointment into the eye, gently blink and then close your eye for 1 to 2 minutes to help the medication reach all the necessary parts of the eye. Press down on the inner corner of your eye near your nose with your finger for 2 to 3 minutes so the medication stays in your eye.
Tips for giving the atropine (Isopto Atropine) eye drops or eye ointment to children:
Have your child lie down on their back on a flat surface. Ask them to tilt their head up and to look up. Then, rest the wrist of the hand that's holding atropine (Isopto Atropine) on your child's forehead.
Pull down your child's lower eyelid with your other hand, and apply the medication along the lower eyelid away from the inner corner near the nose. Afterwards, ask your child to close or blink their eyes for a minute to spread the medication throughout the eye.
Atropine (Isopto Atropine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Atropine (Isopto Atropine) can cause blurry vision. It can also make your eyes be more sensitive to light (squinting or eye discomfort when there's light). These side effects might last up to 2 weeks after you use the eye medication. Consider wearing sunglasses when you step outside after you use atropine (Isopto Atropine). Don't drive a car or operate machinery until you know how the medication affects your vision.
Atropine (Isopto Atropine) might raise your blood pressure. Talk to your healthcare team if you have a history of high blood pressure or are concerned about this possible effect. Your eye specialist might recommend that you check your blood pressure at home if you're using atropine (Isopto Atropine) to treat lazy eye.
Risk factors: Down syndrome | Spastic paralysis | Brain damage
Some people who have had brain damage, have Down syndrome, or have a nerve problem that causes paralysis are at a greater risk of serious side effects from atropine (Isopto Atropine). It can cause damage to their brain function, heart, lungs, or digestive system. Make sure your care team knows your medical history before you start this medication.
People 3 months and older: The typical dose is 1 drop in the affected eye(s) 40 minutes before the dilation time.
People 3 years and older: The typical dose is 1 drop in the affected eye(s) 40 minutes before the dilation time. The dose can be repeated up to 2 times daily as directed by the eye specialist.
The typical dose is to put about a half-inch strip of ointment in the affected eye(s) 1 or 2 times daily, or as directed by the eye specialist.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Primary glaucoma or at risk for a type of glaucoma called narrow-angle glaucoma (eye ointment only)
Pupil dilation (e.g., for eye exams) - eye drops and eye ointment
Temporary paralysis of the eye muscle (cycloplegia) - eye drops and eye ointment
Treatment for lazy eye - eye drops only
Pupil dilation
By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.
Bausch & Lomb Incorporated. (2020). Atropine sulfate ointment [package insert]. DailyMed.
Chia, A., et al. (2016). Five-year clinical trial on atropine for the treatment of myopia 2: Myopia control with atropine 0.01% eyedrops. Ophthalmology.
European Medicines Agency. (2017). Questions and answers and benzalkonium chloride used as an excipient in medicinal products for human use.
Ferris, J. D. (2015). Amblyopia: Atropine. American Academy of Ophthalmology.
Healthychildren.org. (2013). How to give eye drops and eye ointment.
Laspas, P., et al. (2023). Effects of postoperative atropine eye drops on visual quality in patients undergoing trabeculectomy. Journal of Clinical Medicine.
Michelon, H., et al. (2021). Atropine-induced toxicity after off-label sublingual administration of eyedrop for sialorrhoea treatment in neurological disabled patients. British Journal of Clinical Pharmacology.
National Eye Institute. (2024). Types of glaucoma.
Oltra, E. (2015). Amblyopia treatment modalities. American Academy of Ophthalmology.
Raschka, M., et al. (2023). Ophthalmic atropine: A typical anticholinergic toxidrome from an atypical old culprit. The Journal of Pediatric Pharmacology and Therapeutics.
Repka, M. X., et al. (2023). Low-dose 0.01% atropine eye drops vs placebo for myopia control: A randomized clinical trial. Journal of the American Medical Association Ophthalmology.
SafeMedication. (n.d.). How to use eye drops.
SafeMedication. (n.d.). How to use eye ointments and gels.
Somerset Therapeutics, LLC. (2024). Atropine sulfate- atropine sulfate monohydrate solution/ drops [package insert]. DailyMed.
Stellpflug, S. J., et al. (2012). Massive atropine eye drop ingestion treated with high-dose physostigmine to avoid intubation. The Western Journal of Emergency Medicine.
Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.