Key takeaways
Trintellix (vortioxetine) and sertraline (Zoloft) are both medications used to treat depression, but they belong to different drug classes. Trintellix is an atypical antidepressant, while Zoloft is a selective serotonin reuptake inhibitor (SSRI). Trintellix is only approved for treating depression in adults, whereas Zoloft is approved for a wider range of conditions, including major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, and social anxiety disorder. Trintellix is taken once a day and is not available as a generic, while Zoloft is also taken once a day and is available in both tablet and liquid forms, including a generic version. Common side effects for both include nausea and diarrhea, but Zoloft is more likely to cause difficulty sleeping and dry mouth. Both medications can cause withdrawal symptoms if stopped abruptly and have risks of serious side effects like suicidal thoughts and serotonin syndrome.
