Key takeaways
Trintellix (vortioxetine) and Viibryd (vilazodone) are both medications used to treat depression in adults, but they belong to different drug classes. Trintellix is an atypical antidepressant, while Viibryd is a selective serotonin reuptake inhibitor (SSRI) and a serotonin (5HT1A) receptor partial agonist. Trintellix is only available as a brand-name medication, whereas Viibryd is available in both brand and generic forms. Trintellix is taken once daily and can be taken with or without food, but Viibryd must be taken with food to ensure proper absorption. Common side effects of Trintellix include nausea and diarrhea, while Viibryd often causes diarrhea, nausea, and headache. Both medications can cause sexual problems, but Viibryd is noted to have a lower risk of these side effects compared to other antidepressants. Additionally, both Trintellix and Viibryd are less likely to cause weight gain than other antidepressants. Both medications carry risks of serious side effects like suicidal thoughts and serotonin syndrome.
