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Trintellix vs. Prozac

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Trintellix (vortioxetine) and Prozac (fluoxetine) are both medications used to treat depression, but they belong to different drug classes. Trintellix is an atypical antidepressant, while Prozac is a selective serotonin reuptake inhibitor (SSRI). Trintellix is taken once daily and is not available in a generic form, whereas Prozac can be taken once or twice daily and does have a generic version. Prozac is also approved to treat other conditions like obsessive-compulsive disorder (OCD), bulimia, and panic disorder, while Trintellix is only approved for depression. Both medications can cause side effects like nausea and sexual problems, but Prozac is more likely to cause difficulty sleeping. Additionally, Prozac can take up to two months to show full effects, whereas Trintellix might start working in as little as two weeks but can also take up to a month for full benefits.

Trintellix

(vortioxetine)

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Fluoxetine

(Prozac)

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Summary for Trintellix

Prescription only

Trintellix, the brand name for vortioxetine, belongs to a drug class called atypical antidepressants. It's used to treat depression in adults. This medication comes as a tablet that you take by mouth once a day. Common side effects include nausea, diarrhea, and dry mouth. Sexual side effects can also happen, but it's usually less likely than with some other antidepressants. As of 2025, there's no generic version of Trintellix (vortioxetine) available yet.

Indications for Trintellix

Pros and Cons for Trintellix

Pros

Cons

  • Can take up to a month or more before you feel the full effects
  • Not approved for use in children
  • Not approved to treat anxiety

Common Side Effects for Trintellix

  • Nausea (21-32%)
  • Diarrhea (7-10%)
  • Dizziness (6-9%)
  • Dry mouth (6-8%)
  • Vomiting (3-6%)
  • Constipation (3-6%)

Warnings for Trintellix

  • Suicidal thoughts or behavior
  • Serotonin syndrome
  • Higher risk of bleeding
  • Not for use alone for bipolar disorder
  • Withdrawal symptoms
  • Worsening of glaucoma in certain people
  • Low sodium levels
  • Sexual side effects

Summary for Prozac

Prescription only

Fluoxetine (Prozac) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat several mental health conditions, including depression and panic disorder. The immediate-release pill and liquid are taken by mouth, typically once or twice daily. The delayed-release capsule is taken weekly, but it's approved only for depression. Some common side effects of fluoxetine (Prozac) include headaches, difficulty sleeping, and tiredness. Don't suddenly stop this medication if you've been taking it for a while; doing so can lead to symptoms of withdrawal.

Indications for Prozac

Pros and Cons for Prozac

Pros

  • Good choice for treating depression, OCD, and panic disorder
  • Less likely to make you sleepy compared to some other antidepressants, such as paroxetine (Paxil)
  • Taken by mouth, typically once daily (IR capsules and liquid) or once weekly (DR capsules, for depression only)
  • Can be taken with or without food

Cons

  • Can take up to 2 months for you to feel the full effects of the medication
  • Can raise the risk of suicidal thoughts and/or behavior in those age 24 or younger
  • Can interact with other medications, especially those affecting serotonin levels
  • Can cause withdrawal symptoms if you suddenly stop taking it

Common Side Effects for Prozac

  • Difficulty falling asleep (up to 33%)
  • Nausea (up to 29%)
  • Headache (21%)
  • Weakness (up to 21%)
  • Diarrhea (up to 18%)
  • Low appetite (up to 17%)
  • Drowsiness (up to 17%)
  • Anxiety (up to 15%)
  • Nervousness (up to 14%)
  • Tremor (up to 13%)
  • Dry mouth (up to 12%)
  • Throat pain (up to 11%)
  • Yawning (up to 11%)
  • Low sex drive (up to 11%)

Warnings for Prozac

  • Worsening depression, suicidal thoughts and behavior
  • Anxiety and trouble sleeping
  • Serotonin syndrome
  • Severe allergic reactions
  • Not for use alone in bipolar disorder
  • Risk of bleeding
  • Glaucoma
  • Low blood sodium levels
  • Life-threatening abnormal heart rhythm (QT prolongation)

Prices with our coupons for Trintellix vs. Prozac

Price Card Drug Icon
Trintellix30 tablets / 10mg
$299.10$642.69
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Price Card Drug Icon
Fluoxetine30 tablets / 20mg
$9.93$78.85
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