Key takeaways
Saxagliptin (Onglyza) and sitagliptin (Januvia) are both medications used to treat Type 2 diabetes and belong to the same drug class, dipeptidyl peptidase-4 (DPP-4) inhibitors. They help control blood sugar levels by blocking the DPP-4 protein, increasing insulin release in the body and lowering sugar production. However, there are some differences between the two medications. Saxagliptin is typically taken in doses of 2.5 mg or 5 mg once daily, while sitagliptin is usually taken as 25 mg to 100 mg doses once daily. Saxagliptin is available as a generic, while Januvia doesn't have a generic available. Common side effects of saxagliptin include upper respiratory tract infections and headaches, and sitagliptin may cause a runny nose and sore throat. Both medications can cause serious side effects like pancreatitis and joint pain. Always discuss with your healthcare provider about any other medications you are taking, as both can interact with other diabetes medications, potentially leading to low blood sugar.
