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Compare Repatha vs. Praluent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Repatha (evolocumab)
Praluent (alirocumab)
Repatha (evolocumab)
Praluent (alirocumab)
Summary of Repatha vs. Praluent
Summary for PCSK9 inhibitor
Prescription only
Repatha (evolocumab) is a PCSK9 inhibitor that's given as an injection under the skin. It treats high cholesterol in adults and certain children. It works best with a heart-healthy diet and regular exercise. Repatha (evolocumab) also helps lower the risk of events like heart-related death, heart attack, and stroke in adults at risk. The medication is injected either once every 2 weeks or once a month. Side effects can include common cold symptoms and discomfort at the injection site.
Summary for PCSK9 inhibitor
Prescription only
Praluent (alirocumab), is a PCSK9 inhibitor used to treat high cholesterol in certain adults and children, including those with a genetic condition called familial hypercholesterolemia. The medication also helps lower the risk of heart attack, stroke, and hospitalization for chest pain in adults with heart disease. Praluent (alirocumab) is injected under the skin in the thigh, stomach, or upper arm every 2 weeks or 4 weeks, depending on your dose. Common side effects include injection-site reactions, flu or flu-like symptoms (e.g. sneezing, coughing, runny nose), and diarrhea.
Indications of Repatha vs. Praluent
Indications for

•High cholesterol in adults

•Heterozygous familial hypercholesterolemia (HeFH) in people ages 10 years and older

•Homozygous familial hypercholesterolemia (HoFH) in people ages 10 years and older

•Lowering the risk of heart-related death, heart attack, stroke, hospitalization for chest pain, and the need for heart procedures in adults at risk

Indications for

•Lower the risk of heart attack, stroke, and hospitalization for chest pain (angina) in adults with heart disease

•High cholesterol (including heterozygous familial hypercholesterolemia (HeFH)) in adults, alone or with diet and other cholesterol-lowering medications

•Homozygous familial hypercholesterolemia (HoFH) in adults, along with other cholesterol-lowering medications

•Heterozygous familial hypercholesterolemia (HeFH) in children ages 8 and older, along with diet and other cholesterol-lowering medications
Pros and Cons of Repatha vs. Praluent
Pros and Const for PCSK9 inhibitor
Pros

•Taken once every 2 weeks or once a month

•Can use for inherited cholesterol conditions in kids 10 years and up

•Has different injection devices to choose from (prefilled syringe, autoinjector, or on-body infusor)

Cons

•Must give as an injection under the skin

•Might cause reactions at the injection site like redness and pain

•Caution use in people with a latex allergy for syringes and autoinjectors (some have parts made with natural rubber)

Pros and Const for PCSK9 inhibitor
Pros

•Lowers LDL ("bad") cholesterol by about 50% to 60%

•Reduces the risk of heart problems in adults with heart disease

•Used alone or with other cholesterol-lowering medications

•Given either every 2 or 4 weeks

Cons

•Must be injected under the skin

•Side effects include injection-site reactions, flu, and diarrhea

•Potential for serious allergic reactions

•Not known if safe during pregnancy or breastfeeding
Common Side Effects of Repatha vs. Praluent
Common Side Effects for

•Common cold symptoms (4%)

•Back pain (2%)

•Upper respiratory tract infection (2%)

•Joint pain (2%)

•Nausea (2%)

•Tiredness (2%)

Common Side Effects for

•Injection-site reactions (7%)

•Flu or flu-like symptoms (6%)

•Diarrhea (5%)
Warnings of Repatha vs. Praluent
Common Side Effects for

•Allergic reactions

Common Side Effects for

•Serious allergic reaction
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Compare Repatha vs. Praluent

Summary of Repatha vs. Praluent

Indications of Repatha vs. Praluent

Pros and Cons of Repatha vs. Praluent

Common Side Effects of Repatha vs. Praluent

Warnings of Repatha vs. Praluent

Prices with our coupons for Repatha vs. Praluent

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