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Repatha vs. Praluent

Repatha (evolocumab) is a PCSK9 inhibitor that's given as an injection under the skin. It treats high cholesterol in adults and certain children. It works best with a heart-healthy diet and regular exercise. Repatha (evolocumab) also helps lower the risk of events like heart-related death, heart attack, and stroke in adults at risk. The medication is injected either once every 2 weeks or once a month. Side effects can include common cold symptoms and discomfort at the injection site.

• High cholesterol in adults
• Heterozygous familial hypercholesterolemia (HeFH) in people ages 10 years and older
• Homozygous familial hypercholesterolemia (HoFH) in people ages 10 years and older
• Lowering the risk of heart-related death, heart attack, stroke, hospitalization for chest pain, and the need for heart procedures in adults at risk

• Common cold symptoms (4%)
• Back pain (2%)
• Upper respiratory tract infection (2%)
• Joint pain (2%)
• Nausea (2%)
• Tiredness (2%)

• Allergic reactions

Praluent (alirocumab), is a PCSK9 inhibitor used to treat high cholesterol in certain adults and children, including those with a genetic condition called familial hypercholesterolemia. The medication also helps lower the risk of heart attack, stroke, and hospitalization for chest pain in adults with heart disease. Praluent (alirocumab) is injected under the skin in the thigh, stomach, or upper arm every 2 weeks or 4 weeks, depending on your dose. Common side effects include injection-site reactions, flu or flu-like symptoms (e.g. sneezing, coughing, runny nose), and diarrhea.

• Lower the risk of heart attack, stroke, and hospitalization for chest pain (angina) in adults with heart disease
• High cholesterol (including heterozygous familial hypercholesterolemia (HeFH)) in adults, alone or with diet and other cholesterol-lowering medications
• Homozygous familial hypercholesterolemia (HoFH) in adults, along with other cholesterol-lowering medications
• Heterozygous familial hypercholesterolemia (HeFH) in children ages 8 and older, along with diet and other cholesterol-lowering medications

• Injection-site reactions (7%)
• Flu or flu-like symptoms (6%)
• Diarrhea (5%)

• Serious allergic reaction