Nexletol vs. Nexlizet for High Cholesterol: Important Differences and Potential Risks.

Nexletol

(bempedoic acid)

Nexlizet

(bempedoic acid / ezetimibe)

Summary for Nexletol

Prescription only

Nexletol (bempedoic acid) is used treat high cholesterol in adults. This includes people with heterozygous familial hypercholesterolemia (HeFH). It can also help lower the risk of serious problems, like heart attack and stroke, in adults at risk for heart disease who aren't taking statins. Nexletol (bempedoic acid) works as an ATP-citrate lyase (ACL) inhibitor to lower cholesterol. The medication comes as a tablet that's taken by mouth once a day. Side effects can include high uric acid levels and muscle spasms.

Indications for Nexletol

High cholesterol in adults
Heterozygous familial hypercholesterolemia (HeFH) in adults
Lowers the risk of heart-related death, heart attack, stroke, and the need for procedures to improve blood flow to the heart in adults at risk for heart disease who aren't taking a statin

Pros and Cons for Nexletol

Pros

Taken by mouth once per day
An option for people who can't take statins
Can take by itself or with other cholesterol medications

Cons

Only available as a tablet that can't be crushed
Can raise uric acid levels, which can be a cause of gout
Not approved for children

Common Side Effects for Nexletol

High uric acid levels (16%)
Kidney problems (11%)
Anemia (low red blood cell count; 5%)
Higher liver enzyme levels (4%)
Muscle spasms (4%)

Warnings for Nexletol

High uric acid levels
Tendon rupture or injury

Summary for Nexlizet

Prescription only

Nexlizet is a brand-name combination medication that treats adults with high cholesterol, including those with a genetic condition called familial hypercholesterolemia. For adults at risk for heart disease who aren't taking statins, Nexlizet can help lower the risk of heart attack and the need for a procedure to open blocked arteries to help blood flow to the heart (e.g., stent placement). Nexlizet contains bempedoic acid (an ATP-citrate lyase inhibitor) and ezetimibe (a cholesterol absorption inhibitor), which both lower cholesterol. Nexlizet is a tablet that's taken once per day, by itself or with other cholesterol medications. Side effects include high uric acid levels and anemia.

Indications for Nexlizet

Treatment of high cholesterol
Treatment of heterozygous familial hypercholesterolemia (genetic condition that causes high cholesterol)
Lower the risk of heart attack and the need for a heart procedure that opens blocked arteries to help blood flow to the heart (e.g., stent placement) in adults at risk for heart disease

Pros and Cons for Nexlizet

Pros

Taken by mouth once per day
Can take by itself, with a statin, or with other cholesterol-lowering medications
Lowers LDL-C ("bad" cholesterol) by almost 40% after 3 months of taking Nexlizet (bempedoic acid / ezetimibe) with a statin
More convenient to take a single pill with two medications in it

Cons

Can raise uric acid levels, which can be a cause of gout
Not recommended while pregnant or breastfeeding because it's not known how safe the medication is in these situations
Hasn't been studied in children
No lower-cost generic available; brand name only

Common Side Effects for Nexlizet

High uric acid levels
Kidney problems
Anemia (low red blood cell count)
High liver enzyme levels
Muscle spasms
Upper respiratory tract infection
Diarrhea

Warnings for Nexlizet

High uric acid levels
Tendon rupture or injury

Prices with our coupons for Nexletol vs. Nexlizet

Nexletol30 tablets / 180mg

$231.00$513.65

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Nexlizet30 tablets / 180mg/10mg

$231.00$513.11

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Nexletol vs. Nexlizet

Nexletol

Nexlizet

Summary for Nexletol

Indications for Nexletol

Pros and Cons for Nexletol

Pros

Cons

Common Side Effects for Nexletol

Warnings for Nexletol

Summary for Nexlizet

Indications for Nexlizet

Pros and Cons for Nexlizet

Pros

Cons

Common Side Effects for Nexlizet

Warnings for Nexlizet

Prices with our coupons for Nexletol vs. Nexlizet

Compare other High Cholesterol drugs

Browse medications by letter

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Nexletol

Nexlizet

Summary for Nexletol

Indications for Nexletol

Pros and Cons for Nexletol

Pros

Cons

Common Side Effects for Nexletol

Warnings for Nexletol

Summary for Nexlizet

Indications for Nexlizet

Pros and Cons for Nexlizet

Pros

Cons

Common Side Effects for Nexlizet

Warnings for Nexlizet