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Nexletol Coupon - Nexletol 180mg tablet

Nexletol

bempedoic acid
Used for High Cholesterol
Used for High Cholesterol

Nexletol (bempedoic acid) is a brand-name medication that treats adults with high cholesterol, including those with a genetic condition called familial hypercholesterolemia. It also helps lower the risk of heart attack and the need for a procedure that opens blocked arteries to help blood flow to the heart in adults at risk for heart disease who aren't taking statins. Nexletol (bempedoic acid) is an ATP-citrate lyase (ACL) inhibitor that lowers LDL-C (low-density lipoprotein cholesterol). Nexletol (bempedoic acid) is a tablet that's taken by mouth once per day. Side effects include having high uric acid levels and muscle spasms.

Last reviewed on July 11, 2024
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What is Nexletol (bempedoic acid)?

What is Nexletol (bempedoic acid) used for?

How Nexletol (bempedoic acid) works

Nexletol (bempedoic acid) is an ATP-citrate lyase (ACL) inhibitor. ACL is a protein in your body that's involved in making cholesterol in your liver. Nexletol (bempedoic acid) works by blocking ACL. This helps stop your body from making LDL-C (low-density lipoprotein cholesterol), also known as "bad cholesterol." As a result, the medication helps lower LDL-C levels in your blood.

Are you looking for information on Nexlizet (bempedoic acid / ezetimibe) or Nexplanon (etonogestrel) instead?

Drug Facts

Common BrandsNexletol
Drug ClassACL inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Nexletol (bempedoic acid) essentials

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What are the side effects of Nexletol (bempedoic acid)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • High uric acid level—severe pain, redness, warmth, or swelling in joints, pain or trouble passing urine, pain in the lower back or sides
  • Joint, muscle, or tendon pain, swelling, or stiffness

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Nexletol (bempedoic acid)

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Pros

Taken by mouth once per day

Can take by itself, with a statin, or with other cholesterol-lowering medications

Lowers LDL-C (bad cholesterol) by an average of almost 20% after 3 months of taking Nexletol (bempedoic acid) with a statin

Can take if you have mild-to-moderate kidney or liver problems

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Cons

Only available as a tablet that can't be crushed

Can raise uric acid levels, which can be a cause of gout

Hasn't been studied in children, so it's not known how safe or how well the medication is for them

No lower-cost generic available; brand name only

pharmacist-tips

Pharmacist tips for Nexletol (bempedoic acid)

pharmacist
  • It can take a few months for your cholesterol levels to drop after you start treatment with Nexletol (bempedoic acid). Follow up with your prescriber when instructed to get a blood test done to check your lipid panel (the levels of different kinds of cholesterol and fats in your blood). This will help you and your prescriber see how well Nexletol (bempedoic acid) is working for you.

    • Take Nexletol (bempedoic acid) with or without food. You can try taking it with food to help with any upset stomach you might have from the medication.

      • Swallow the Nexletol (bempedoic acid) tablets whole. Let your prescriber know if you're having trouble swallowing them. Discuss with your prescriber whether there's a different cholesterol-lowering medication that might be easier for you to take.

        • Limit or avoid alcohol while you're taking Nexletol (bempedoic acid). Both alcohol and Nexletol (bempedoic acid) can raise the risk for liver problems. In addition, drinking a lot of alcohol can make your cholesterol go up. Speak with your prescriber about your drinking habits and how to safely take Nexletol (bempedoic acid).

          • It's not recommended to take more than 20 mg of simvastatin (Zocor) or 40 mg of pravastatin (Pravachol) per day with Nexletol (bempedoic acid). The levels of these particular statins can rise in the body when you take them with Nexletol (bempedoic acid). This can raise your risk for statin-related muscle pain. Let your prescriber know if you feel muscle pain if you're taking Nexletol (bempedoic acid) with a statin.

            faqs

            Frequently asked questions about Nexletol (bempedoic acid)

            How much does Nexletol (bempedoic acid) lower cholesterol?
            People who took Nexletol (bempedoic acid) had an almost 20% average drop in their LDL-C ("bad cholesterol") levels after about 3 months of treatment in a study comparing Nexletol (bempedoic acid) to a placebo. Keep in mind that most people in the study were also taking other cholesterol-lowering therapy, such as a statin, at the same time. Make sure to get your cholesterol tests done on time so you and your prescriber can discuss how well Nexletol (bempedoic acid) is working for you at your follow-up visits.
            Does Nexletol (bempedoic acid) lower triglycerides?
            The effect that Nexletol (bempedoic acid) might have on triglycerides, a type of fat, isn't clear. There were mixed results from a group of studies with people who took Nexletol (bempedoic acid) with other cholesterol-lowering therapy for 3 months. One study showed that some people had slightly raised triglyceride levels and another study found that some people had slightly lower triglyceride levels at the end of the study. But overall, Nexletol (bempedoic acid) appears that it doesn't affect triglyceride levels by much. Talk with your prescriber about a treatment plan that's best for you if you have high triglyceride levels.
            Is Nexletol (bempedoic acid) a statin?
            No, Nexletol (bempedoic acid) isn't a statin. Instead, it's an ATP-citrate lyase (ACL) inhibitor. Both ACL inhibitors and statins help lower "bad" cholesterol (LDL-C). But they work in different ways to stop your body from making cholesterol. Your primary care provider or cardiologist might recommend that you take Nexletol (bempedoic acid) and a statin together if your cholesterol levels are still high after you take one of these medications by itself.
            What's the difference between Nexletol and Nexlizet?
            Both Nexletol and Nexlizet contain bempedoic acid. But Nexlizet is a combination medication. In addition to bempedoic acid, Nexlizet also contains ezetimibe (Zetia), which is a different medication that works in another way to help lower cholesterol levels further. Your prescriber might prefer that you take Nexlizet if you need to take multiple medications in addition to following a heart-healthy diet to help with your cholesterol.
            Does Nexletol (bempedoic acid) cause weight gain?
            Nexletol (bempedoic acid) doesn't appear to cause weight gain; there weren't any reports of weight gain from people who took the medication during clinical studies. A study actually showed that some people with diabetes or prediabetes along with high cholesterol who took Nexletol (bempedoic acid) for 3 months experienced very little weight loss (less than a pound on average). Speak with your care team if you notice unexpected changes in weight during treatment with Nexletol (bempedoic acid).
            Does Nexletol (bempedoic acid) cause hair loss?
            Hair loss wasn't reported from people who took Nexletol (bempedoic acid) during clinical studies. Contact your healthcare team if you notice hair loss while you're taking this medication. They can help you figure out possible causes for your hair loss.
            Is there a generic for Nexletol (bempedoic acid)?
            No. Nexletol (bempedoic acid) is currently available as a brand-name medication only.
            Is Nexletol (bempedoic acid) safe while pregnant or breastfeeding?
            It's not known whether Nexletol (bempedoic acid) is safe to take while pregnant or breastfeeding because there haven't been enough research about this. So, it's generally recommended to avoid using Nexletol (bempedoic acid) while you're pregnant or breastfeeding unless the benefits clearly outweigh the risks. Speak with a healthcare professional to see whether this medication is right for you if you're pregnant, thinking of getting pregnant, or breastfeeding. And tell your prescriber if you become pregnant during treatment. It's recommended that your pregnancy gets reported to the manufacturer (Esperion Therapeutics) at 1-833-377-7633 so researchers can follow your health and your baby's health after exposure to the medication during pregnancy.
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            What are the risks and warnings for Nexletol (bempedoic acid)?

            Nexletol (bempedoic acid) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            High uric acid levels

            • Risk factors: History of gout

              Nexletol (bempedoic acid) can raise your uric acid levels in the blood. This usually starts to happen within the first month of taking Nexletol (bempedoic acid). High uric acid levels can lead to symptoms of gout, like pain, redness, and tenderness in your joints. Contact your prescriber if you have any gout symptoms. Your prescriber might need to check your uric acid levels through blood work. Depending on your lab results, your prescriber might recommend that you start taking medications that help lower your uric acid levels.

              risk-warning

              Tendon rupture or injury

              • Risk factors: Age older than 60 years | Taking corticosteroids or certain antibiotics with Nexletol (bempedoic acid) | Kidney failure | History of tendon problems

                Although very rare, it's possible for Nexletol (bempedoic acid) to raise the risk for injury or rupture in your tendons. In clinical trials, tendon rupture happened in fewer than 1% of people who took Nexletol (bempedoic acid). These injuries happened in the shoulder, biceps, or Achilles heel. And they happened within the first weeks to months of treatment.

                The risk for tendon injuries might be higher in people older than 60 years old, people taking corticosteroids or certain antibiotics like ciprofloxacin (Cipro), people with kidney failure, and people with a history of tendon problems. Don't exercise or do anything that could worsen your injury if you have any pain or swelling in a joint or if you have difficulty moving a joint. Contact your prescriber right away if you have symptoms of tendon problems because you might have to stop taking Nexletol (bempedoic acid).

                dosage

                Nexletol (bempedoic acid) dosage forms

                The average cost for 30 tablets of 180mg of Nexletol (bempedoic acid) is $10.00 with a free GoodRx coupon. This is 98.04% off the average retail price of $509.75.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                180mg30 tablets$10.00$0.33

                Typical dosing for Nexletol (bempedoic acid)

                The typical dose is 180 mg by mouth once per day.

                More on Nexletol (bempedoic acid) dosage forms

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                alternatives

                What are alternatives to Nexletol (bempedoic acid)?

                There are a number of medications that your doctor can prescribe in place of Nexletol (bempedoic acid). Compare a few possible alternatives below.
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                Nexletol (bempedoic acid) images

                White Oval Esp And 180 - NEXLETOL 180mg Tablet
                This medicine is White, Oval Tablet Imprinted With "180" And "Esp".White Oval Esp And 180 - NEXLETOL 180mg Tablet

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                References

                Best studies we found

                Centers for Disease Control and Prevention. (2024). About familial hypercholesterolemia.

                Drugs and Lactation Database (LactMed). (2023). Bempedoic acid. National Institute of Child Health and Human Development.

                Esperion Therapeutics, Inc. (2024). NEXLETOL- bempedoic acid tablet, film coated [package insert]. DailyMed.

                View All References (6)

                Leiter, L. A., et al. (2022). Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: A post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials. Diabetes, Obesity and Metabolism.

                McGowan, M. P., et al. (2019). Diagnosis and treatment of heterozygous familial hypercholesterolemia. Journal of the American Heart Association.

                MedlinePlus. (2022). Uric acid test.

                MedlinePlus. (2023). Uric acid - blood.

                National Institute of Diabetes and Digestive and Kidney Diseases. (n.d.) Gallstones.

                Ray, K. K., et al. (2019). Safety and efficacy of bempedoic acid to reduce LDL cholesterol. The New England Journal of Medicine.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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