Key takeaways:
Gout is a common type of arthritis that causes sudden episodes of joint pain and swelling. It can affect one or multiple joints.
Left untreated, gout can become chronic. With chronic gout, uric acid deposits called tophi develop in the skin and joints.
Medications that lower uric acid levels can help prevent future gout attacks and long-term joint damage.
Gout is a common type of arthritis that causes sudden pain and swelling in one or more joints. It develops in some people who have high levels of uric acid in their blood. Uric acid, a natural waste product, forms crystals that can deposit in joints and the skin. This causes pain and inflammation.
Knowing the signs and symptoms of gout is the first step in getting the right diagnosis. Luckily, gout has some pretty unique features at every stage that can make it easy to spot.
It can take many years to progress from your first attack of gout (stage 1) to chronic gout (stage 4). Getting diagnosed and treated early can prevent the progression to chronic gout. It’s possible to never develop chronic gout and to never deal with another gout flare again.
Here are the four stages of gout.
People in this early stage have high levels of uric acid in their blood (hyperuricemia) but haven’t yet developed symptoms. There’s no way of knowing you have a high uric acid level unless it’s picked up on a blood test. Not everyone with high uric acid levels will develop gout.
At first, gout flares usually involve one joint at a time. Typically, gout starts in a big toe or a knee. But gout can affect any joint.
After a while, flares can involve multiple joints at once (like all the joints in your foot).
Gout flares usually get better within 1 to 2 weeks.
This is the stage in between gout flares. For some people, this stage may last years. In other words, it may be years before they have another gout flare after their first gout episode. For others, gout flares may happen every few months or even weeks.
Without gout treatment, gout flares happen more often.
If you continue having recurrent gout flares, gout can progress to this chronic stage. With chronic gout, you can have joint pain and swelling that doesn’t improve between episodes.
People with chronic gout also develop “tophi.” These are collections of uric acid crystals in the joints and underneath the skin. They look like chalky, white bumps. Chronic tophaceous gout can cause permanent joint damage and deformities. The good news? It’s preventable with gout treatment.
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Gout and your diet: A nutritious and balanced diet may be more important than completely eliminating a particular food. But avoiding foods high in purine can help to prevent flares.
Dealing with a painful, swollen joint? There are many different types of arthritis, and knowing which one you have is the first step to getting the right treatment.
A gout attack causes sudden swelling, redness, and pain in and around the joint. Gout often involves the big toe (called podagra), but other joints can be affected too.
In chronic gout, tophi can develop, especially near the knees, elbows, fingers, and ears. Tophi can be chalky white, yellow, or skin-colored. Some are smaller than a pencil eraser, while others can be several inches wide. Sometimes, they can break through the skin, releasing tiny amounts of chalky, white material.
Here are some pictures of chronic gout with tophi and swollen joints in different parts of the body.
The best way to diagnose gout is with a joint aspiration. In this office procedure, your healthcare professional (usually a rheumatologist) will use a needle and syringe to withdraw a small amount of fluid from your joint. They will then look at the fluid under a microscope to see if there are uric acid crystals.
In some cases, your healthcare professional can diagnose gout without a joint aspiration. They may be able to do this based on your symptoms, physical exam, and blood test results. An X-ray can also help rule out other causes of joint pain.
Treating gout is a two-pronged approach. The first step is to treat the active gout attack. The second step is to prevent future gout flares.
Treatment for an active gout flare: Gout attacks are treated with medications like colchicine, prednisone, and nonsteroidal anti-inflammatory drugs (NSAIDS). A steroid injection into an affected joint might also be an option.
Preventing future gout flares: Longer-term prevention focuses on lowering uric acid blood levels below 6.0 mg/dL so that gout attacks can’t happen. For this, you have to take medications like allopurinol and febuxostat every day.
When you start gout prevention treatment:
Start with a low dose of allopurinol or febuxostat.
Gradually increase the dose until uric acid level drops below 6 mg/dL.
Continue taking medication to treat gout (like colchicine, prednisone, or NSAIDs) during this time.
Once uric acid level is under 6 mg/dL and you’ve had no gout flares for one month, you can stop the active gout treatment and continue the preventative gout treatment.
Lifestyle changes, like changing your diet and maintaining a weight that feels best, are helpful for your overall health. But without gout medications, this is usually not enough to prevent gout episodes.
You should always get emergency medical attention if you suddenly develop a painful, swollen joint that you can barely move, and a fever. It could be a joint infection, which may have serious consequences. For less severe symptoms, call your doctor’s office as soon as possible to determine the next best steps.
When levels of uric acid change rapidly (either up or down), this can trigger a gout attack.
Uric acid levels can increase quickly if:
You eat a lot of high-purine foods, like red meat, shellfish, alcohol, or high-fructose corn syrup
You stop your gout medications
Uric acid levels can decrease quickly if:
You start a new medication like hydrochlorothiazide (Microzide) or furosemide (Lasix)
You have major surgery or a severe medical illness
You are seriously dehydrated
You start a long-term gout prevention medication (like allopurinol or febuxostat) without also taking a medication for flare prevention (colchicine, prednisone, or NSAIDs)
If you develop a swollen, inflamed, and painful joint, it may not be gout. There are some other conditions that cause similar symptoms, so it’s important to get checked out by your medical care team to rule out:
Septic arthritis (infected joint)
A joint injury
The best (and only) way to meaningfully lower uric acid levels is to take gout prevention medication (like allopurinol) every day. Dietary and lifestyle changes can help improve your overall health, but they won’t help lower uric acid enough to prevent gout episodes and chronic gout.
That said, it helps to avoid the following foods and drinks that can rapidly increase uric acid levels:
Alcohol
Red meat
Shellfish
Sugary foods and drinks that contain high-fructose corn syrup
Gout is a common and treatable type of arthritis. An acute gout attack can come out of the blue but take up to 2 weeks to get better. Untreated, chronic gout can cause uric acid deposits in the skin and joints. These tophi look like white, yellow, or skin-colored growths. Over time, they can build up and cause permanent joint damage and deformity.
Gout is treatable. Some medications, like NSAIDs, treat gout attacks by lowering inflammation. Other medications prevent gout from coming back by lowering uric acid levels in the body.
Images used with permission from VisualDx (www.visualdx.com).
Dunkin, M. A. (2022). 4 stages of gout and the early signs to watch out for. Arthritis Foundation.
Fenando, A., et al. (2024). Gout. StatPearls.