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Myrbetriq vs. Detrol

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Myrbetriq (mirabegron) and tolterodine (Detrol) are both used to treat overactive bladder (OAB) symptoms, but they work in different ways. Myrbetriq is a beta-3 adrenergic agonist that helps your bladder relax so it can hold more urine, while tolterodine is an anticholinergic medication that blocks certain receptors to relax bladder muscles and control spasms. Myrbetriq is taken once daily and is available only as a brand-name medication, whereas tolterodine comes in both immediate-release and extended-release forms, with generic versions available. Common side effects of Myrbetriq include high blood pressure and urinary tract infections, while tolterodine often causes dry mouth, headache, and dizziness. Myrbetriq might be safer for older adults and causes less drowsiness and constipation compared to other OAB medications, but it can raise blood pressure. Tolterodine can cause severe dry mouth and constipation and may increase the risk of falls due to dizziness or drowsiness.

Myrbetriq

(mirabegron)

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Tolterodine

(Detrol)

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Summary for Myrbetriq

Prescription only

Myrbetriq (mirabegron) is used to help with overactive bladder (OAB) in adults. It can also treat a bladder problem called neurogenic detrusor overactivity (NDO) in children 3 years and older. It works as a beta-3 adrenergic agonist to help the bladder hold more urine. Myrbetriq (mirabegron) is taken by mouth once a day. It comes as a brand-name or generic extended-release tablet. A solution made from granules of the medication is available for children, but it's brand name only. Side effects include high blood pressure, cold symptoms, and urinary tract infections.

Indications for Myrbetriq

Pros and Cons for Myrbetriq

Pros

Cons

  • Might raise your blood pressure
  • Might have trouble fully emptying your bladder if you have a blockage in your bladder or if you also take anticholinergics for bladder control
  • Not recommended if you have severe kidney or liver problems

Common Side Effects for Myrbetriq

Adults:

Children:

  • Urinary tract infection (24%)
  • Common cold symptoms (6%)
  • Constipation (5%)
  • Headache (4%)
  • Nausea (2%)

Warnings for Myrbetriq

  • High blood pressure
  • Risk of having trouble fully emptying the bladder in certain people
  • Unusual swelling of the face, lips, or throat (angioedema)
  • Interactions with other medications

Summary for Detrol

Prescription only

Tolterodine (Detrol) is used to treat overactive bladder (OAB) in adults. It's an anticholinergic medication that helps with bladder control to lessen the need to go to the restroom suddenly or often. The immediate-release tablet (Detrol) is taken by mouth twice a day. There's also an extended-release capsule (Detrol LA) that's taken just once a day. Both formulations come in brand-name and generic-name versions. Tolterodine (Detrol) can commonly cause dry mouth. Other side effects can include headache and constipation.

Indications for Detrol

Pros and Cons for Detrol

Pros

  • Works well to help lessen your urge to urinate
  • Might cause less dry mouth than oxybutynin
  • Also available in an extended-release version that's taken only once a day

Cons

  • Can cause uncomfortable dry mouth and constipation
  • Can make you feel sleepy or dizzy, which can raise your risk of falls
  • Can't take if you have an allergy to another OAB medication called Toviaz (fesoterodine)

Common Side Effects for Detrol

Immediate-release tablets:

  • Dry mouth (35%)
  • Headache (7%)
  • Constipation (7%)
  • Stomach pain (5%)
  • Dizziness or feeling like you're spinning (5%)

Extended-release capsules:

  • Dry mouth (23%)
  • Headache (6%)
  • Constipation (6%)
  • Stomach pain (4%)

Warnings for Detrol

  • Serious allergic reaction and swelling (angioedema)
  • Dizziness and drowsiness
  • Caution use in people with narrow-angle glaucoma
  • Caution use in people with trouble urinating
  • Caution use in people with problems causing gut blockage
  • Caution use in people with myasthenia gravis
  • Caution use in people with certain heart rhythm problems

Prices with our coupons for Myrbetriq vs. Detrol

Price Card Drug Icon
Mirabegron30 tablets / 50mg
$117.62$248.30
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Price Card Drug Icon
Tolterodine60 tablets / 2mg
$27.73$169.11
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