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Janumet vs. Metformin

Janumet (sitagliptin / metformin) is a medication for adults with Type 2 diabetes. It contains two different diabetes medications that work together to help control blood sugar. One is sitagliptin, a DPP-4 inhibitor, and the other is metformin, a biguanide. The Janumet immediate-release tablets are taken by mouth twice a day. It works best when used with a balanced meal plan and exercise routine. Some side effects are diarrhea, upper respiratory tract infection, and headache. There's only a brand-name version of Janumet; there's no generic version yet.

• Type 2 diabetes

• Diarrhea (8%)
• Upper respiratory tract infection (6%)
• Headache (6%)

• Lactic acidosis
• Inflammation of the pancreas (pancreatitis)
• Risk of heart failure
• Sudden kidney problems
• Low vitamin B12 levels
• Low blood sugar (hypoglycemia) when taken with certain diabetes medications
• Joint pain
• Severe skin reaction
• Serious allergic reactions

Immediate-release metformin is an oral diabetes medication. It's approved for people 10 years of age and older with Type 2 diabetes. The medication belongs to the drug class called biguanides. It works best to lower blood sugar levels with a diabetes-friendly diet and exercise plan. Immediate-release metformin comes as a tablet and an oral solution. You take this medication by mouth usually two to three times a day. It's recommended to take each dosage with food to help lessen side effects like diarrhea and nausea.

• Type 2 diabetes in people ages 10 years and older

• Diarrhea (53%)
• Nausea or vomiting (26%)
• Gas (12%)
• Weakness (9%)

• Lactic acidosis
• Low vitamin B12 levels
• Low blood sugar (hypoglycemia) when taken with certain other diabetes medications