Key takeaways
Itraconazole (Sporanox, Tolsura) and terbinafine (Lamisil) are both antifungal medications used to treat fungal infections, including those affecting the nails. However, they differ in several ways. Itraconazole is available in capsule form and is used for severe fungal infections like blastomycosis, histoplasmosis, and aspergillosis, as well as fungal nail infections. Terbinafine, on the other hand, is primarily used for fungal nail infections and is taken as a tablet. Itraconazole must be taken with food, while terbinafine can be taken with or without food. Itraconazole has a higher risk of serious side effects, such as heart problems and liver damage, and interacts with many medications. Terbinafine can also cause liver damage and may affect your sense of taste or smell, sometimes permanently. Both medications are available as generics, but terbinafine is often considered a first-choice treatment for nail fungus due to its effectiveness and simpler dosing.
