Key takeaways
Sumatriptan (Imitrex) and Treximet (sumatriptan/naproxen) are both used to treat migraines, but they have some key differences. Sumatriptan is a triptan that works by tightening blood vessels in the brain and reducing inflammation. It is available as a lower-cost generic tablet. Treximet, on the other hand, combines sumatriptan with naproxen, an NSAID that also helps reduce pain and inflammation. Treximet is not available as a generic and is typically used when other migraine medications haven't worked. While both medications can be taken with or without food and require a second dose if the migraine persists, Treximet is approved for use in children aged 12 and older, whereas sumatriptan is not. Additionally, Treximet carries a higher risk of serious side effects like stomach bleeding and heart problems due to the naproxen component. Both medications can cause serotonin syndrome and should not be taken with certain antidepressants.
