Key takeaways
Ibsrela (tenapanor) and Motegrity (prucalopride) are both prescription medications used to treat constipation, but they work in different ways and are used for different types of constipation. Ibsrela (tenapanor) is for irritable bowel syndrome with constipation (IBS-C) in adults and is taken twice a day before meals. It works by preventing sodium absorption in the gut, which increases water in the intestines to soften stool and works on the nerves in the gut to relieve stomach pain. The most common side effect is diarrhea. On the other hand, Motegrity is used for chronic idiopathic constipation (CIC) in adults and is taken once daily. It works by stimulating serotonin receptors in the colon to promote muscle contractions and move stool through the digestive tract. Common side effects include headache, stomach pain, and nausea. Unlike Ibsrela, Motegrity can cause serious mood changes, including suicidal thoughts. Both medications are not recommended for children and have specific contraindications related to gut blockages.
