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Focalin vs. Provigil

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Dexmethylphenidate (Focalin, Focalin XR) and modafinil (Provigil) are both prescription medications, but they serve different purposes and belong to different drug classes. Dexmethylphenidate is a stimulant used to treat attention deficit-hyperactivity disorder (ADHD) in both adults and children. It works by increasing levels of norepinephrine and dopamine in the brain. Modafinil, on the other hand, is a wakefulness-promoting agent used to treat excessive sleepiness caused by narcolepsy, obstructive sleep apnea, or shift work disorder. While both medications can cause side effects like headaches and nausea, dexmethylphenidate is a Schedule II controlled substance with a higher risk of misuse and dependence compared to modafinil, which is a Schedule IV controlled substance. Additionally, dexmethylphenidate is available in both immediate-release and extended-release forms, whereas modafinil is available in one form that's typically taken once daily. Both medications require careful monitoring by your healthcare provider due to their potential side effects and interactions with other medications.

Focalin

(dexmethylphenidate)

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Modafinil

(Provigil)

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Summary for Focalin

Prescription only

Dexmethylphenidate (Focalin, Focalin XR) is a stimulant medication that's used for treating attention deficit-hyperactivity disorder (ADHD) in adults and children. It's thought to work by balancing certain chemicals in your brain to help you focus. This medication is available as an immediate-release tablet that you take twice per day and an extended-release capsule you take once per day. Side effects can include stomach upset and nervousness. It can also cause withdrawal symptoms if it's suddenly stopped after long-term use. Focalin (dexmethylphenidate) is available as both a brand-name and lower-cost generic medication.

Indications for Focalin

  • Attention deficit-hyperactivity disorder (ADHD)

Pros and Cons for Focalin

Pros

  • Works well to treat ADHD in children and adults
  • Available as immediate-release tablets and extended-release capsules for a more flexible dosing schedule
  • Available as a lower-cost generic

Cons

  • A controlled substance because of the risk for misuse and dependency
  • Might cause trouble sleeping if you take too late in the day
  • Not the best option if you have heart problems
  • Not available as a liquid

Common Side Effects for Focalin

Immediate-release tablet Age 6 to 17 years:

  • Stomach pain (15%)
  • Nausea (9%)
  • Low appetite (6%)

Extended-release capsule Age 6 to 17 years:

  • Difficulty sleeping (up to 17%)
  • Vomiting (up to 9%)
  • Low appetite (up to 7%)

Age 17 to 60 years:

  • Headache (up to 39%)
  • Dry mouth (up to 20%)
  • Anxiety (up to 11%)
  • Indigestion (up to 9%)
  • Throat pain (up to 7%)

Warnings for Focalin

  • Misuse and dependence
  • Serious heart problems
  • Changes in behavior or thoughts
  • Prolonged and painful erection
  • Problems with blood circulation (Raynaud's phenomenon)
  • Slowed growth in children
  • Serotonin syndrome
  • Drug interactions

Summary for Provigil

Prescription only

Modafinil (Provigil) helps improve wakefulness in adults with narcolepsy, obstructive sleep apnea, or shift work disorder. This wake-promoting medication comes as a tablet that’s taken by mouth. For adults with narcolepsy or sleep apnea, you take a dosage once daily in the morning. And for those with shift work disorder, you take your dosage 1 hour before the start of your work shift. Common side effects include headache and nausea. Modafinil (Provigil) is a controlled substance because of its potential for misuse.

Indications for Provigil

Pros and Cons for Provigil

Pros

Cons

Common Side Effects for Provigil

  • Headache (34%)
  • Nausea (11%)
  • Feeling nervous (7%)
  • Runny nose (7%)
  • Back pain (6%)
  • Diarrhea (6%)
  • Anxiety (5%)
  • Dizziness (5%)
  • Indigestion (5%)
  • Trouble sleeping (5%)

Warnings for Provigil

  • Serious allergic reactions
  • Serious rash and skin reactions
  • Sleepiness and trouble focusing, thinking, and reacting
  • Unusual changes in mood and behavior
  • Heart problems
  • Changes in blood pressure and heart rate

Prices with our coupons for Focalin vs. Provigil

Price Card Drug Icon
Dexmethylphenidate60 tablets / 10mg
$25.01$117.12
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Price Card Drug Icon
Modafinil30 tablets / 200mg
$22.28$137.54
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