Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Modafinil (Provigil) and dextroamphetamine (Dexedrine) are both prescription medications, but they serve different purposes and belong to different drug classes. Modafinil is a wakefulness-promoting agent used to treat excessive sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. On the other hand, dextroamphetamine is a stimulant used primarily for treating attention deficit-hyperactivity disorder (ADHD) and narcolepsy. Modafinil is typically taken once daily, while dextroamphetamine can be taken in immediate-release or extended-release forms, with dosing varying based on age and condition. Modafinil is a Schedule IV controlled substance, indicating a lower potential for misuse compared to dextroamphetamine, which is a Schedule II controlled substance with a higher risk of misuse and dependence. Common side effects of modafinil include headache and nausea, whereas dextroamphetamine commonly causes fast heartbeat, loss of appetite, and trouble sleeping. Both medications have serious side effects and interactions, so it's important to take them exactly as prescribed and discuss any concerns with your healthcare provider.
Modafinil (Provigil)
Dextroamphetamine
Modafinil (Provigil)
Dextroamphetamine
Summary of Provigil vs. Dexedrine
Summary for Wakefulness-promoting agent
Prescription only
Modafinil (Provigil) is a prescription medication used to improve wakefulness in people who have extreme sleepiness due to narcolepsy, obstructive sleep apnea, or shift work disorder. It's considered a controlled substance since this medication has a potential to cause misuse. You should avoid alcohol while taking modafinil (Provigil), as well as certain other medications to avoid any serious interactions and side effects. Common side effects of modafinil (Provigil), however, include headache and nausea.
Summary for Stimulant
Prescription only
Dextroamphetamine is used for the treatment of attention deficit-hyperactivity disorder (ADHD). It can also be used to treat uncontrollable daytime sleepiness (narcolepsy). Some side effects of the medication include difficulty sleeping, restlessness, and loss of appetite (that might lead to possible weight loss).