Key takeaways
Estazolam (formerly branded as Prosom) and Hetlioz (tasimelteon) are both used to help with sleep issues, but they work in different ways and are used for different conditions. Estazolam is a benzodiazepine that helps you fall asleep and stay asleep by slowing down brain activity. It's only available as a generic and is meant for short-term use due to the risk of dependence and misuse. On the other hand, Hetlioz is a melatonin receptor agonist that helps regulate sleep cycles, especially for people who are totally blind with non-24-hour sleep-wake disorder or those with Smith-Magenis Syndrome. Hetlioz is available in brand and generic forms. Unlike estazolam, Hetlioz is not habit-forming and needs to be taken at the same time every night on an empty stomach. Estazolam works quickly, while Hetlioz can take weeks to months to show effects. Additionally, estazolam is a controlled substance, whereas Hetlioz is not.
