Key takeaways
Divalproex (Depakote) and topiramate (Topamax) are both antiepileptic medications used to treat seizures and prevent migraines, but they have some key differences. Divalproex is also used to treat bipolar disorder, while topiramate is not. Divalproex works by increasing gamma-aminobutyric acid (GABA) in the brain to reduce seizure activity, whereas topiramate blocks certain brain signals to prevent seizures. Divalproex is available in delayed-release and extended-release tablets, as well as sprinkle capsules, while topiramate comes in immediate-release and extended-release tablets, capsules, and a liquid form. Both medications can cause serious side effects, but topiramate can cause kidney stones, while divalproex can cause liver problems and pancreatitis. Additionally, both medications can cause weight changes, but divalproex can lead to both weight gain and weight loss, whereas topiramate is more commonly associated with weight loss. Both medications should not be taken during pregnancy due to the risk of birth defects.
