Key takeaways
Duloxetine (Cymbalta) and alprazolam (Xanax) are both medications used to treat generalized anxiety disorder (GAD), but they belong to different medication classes. Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) that is also approved for treating major depressive disorder, diabetic neuropathy, fibromyalgia, and long-term pain in adults. Alprazolam, on the other hand, is a benzodiazepine that is also approved for treating panic disorder. Duloxetine is typically taken once daily, while alprazolam is usually taken three times a day. Alprazolam also comes in an extended-release form (Xanax XR) that's typically taken once a day. Both medications are available as lower-cost generics. Alprazolam is a controlled substance due to its potential for dependence and misuse, but duloxetine is not. Common side effects of duloxetine include nausea and headache, whereas alprazolam often causes drowsiness and memory problems. You should avoid alcohol with both medications, but the risk of serious interactions is higher with alprazolam. Additionally, duloxetine can cause withdrawal symptoms if stopped abruptly, similar to alprazolam, but alprazolam tends to have a higher risk of serious side effects and withdrawal symptoms.
