Soluble guanylate cyclase (sGC) stimulators are used to treat chronic heart failure, pulmonary arterial hypertension (PAH), and chronic thromboembolic pulmonary hypertension (CTEPH). They work by activating sGC, which helps relax blood vessels and improve blood flow. These medications are available in oral form. Examples include Verquvo (vericiguat) and Adempas (riociguat).