Gliptin / biguanide combinations are used to treat Type 2 diabetes. They work by combining two types of diabetes treatments: gliptins, which increase insulin production and decrease glucose (sugar) production in the liver, and biguanides, which improve the body's response to insulin and reduce glucose absorption in the intestines. These medications are available as oral tabletd. Examples include sitagliptin / metformin (Janumet, Janumet XR), alogliptin / metformin (Kazano), and saxagliptin / metformin (Kombiglyze XR). You can discuss with your healthcare team which option might be right for you.