Dicyclomine, also known by its brand name Bentyl, is an anticholinergic medication that's used to treat spasms of the muscles in the stomach and intestines in adults with irritable bowel syndrome (IBS). This medication is available as generic tablets, capsules, and liquid that are taken by mouth four times daily. There's also an injection form of dicyclomine that's available as brand name and generic; it's injected into the muscle for people who can't take pills by mouth. Common side effects include dizziness, dry mouth, and blurry vision.
Dicyclomine is an anticholinergic medication. It works by blocking a chemical called acetylcholine from attaching to receptors in your stomach and intestines. Typically, acetylcholine causes the muscles in your gut to contract.
By blocking acetylcholine, dicyclomine relaxes the muscles in the stomach and intestines to lessen cramping in people with IBS.
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Contact your healthcare provider immediately if you experience any of the following.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Rare
Confusion (especially in the elderly)
dizziness, lightheadedness that continues, or fainting
skin rash or hives
Incidence not known
difficulty with swallowing
fast irregular, pounding, or racing heartbeat or pulse
hives or welts
hoarseness
irritation
itching skin
joint pain, stiffness, or swelling
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
redness of the skin
shortness of breath
skin rash
tightness in the chest
trouble with breathing
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
Bloated feeling
blurred vision
difficult urination
difficulty with swallowing
drowsiness
false sense of well-being
headache
increased sensitivity of eyes to light
loss of memory
nausea or vomiting
redness or other signs of irritation at the place of injection
trouble with sleeping
unusual tiredness or weakness
Incidence not known
Decreased interest in sexual intercourse
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
loss of taste
For patients using scopolamine:
After you stop using scopolamine, your body may need time to adjust. The length of time this takes depends on the amount of scopolamine you were using and how long you used it. During this period of time check with your doctor if you notice any of the following side effects:
irritability
nightmares
pupil of one eye is larger (patch only)
sensitivity of eyes to light (patch only)
trouble in sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
The brand name Bentyl is available only as the injection form of dicyclomine that's given into the muscle for people who can't take the medication by mouth. Bentyl tablets, capsules, and oral solution have been discontinued, but they're still available under the generic name dicyclomine.
One study showed that people started to feel an improvement in symptoms like stomach pain and tenderness within 2 weeks of taking dicyclomine. Keep in mind that each person can have a different experience with the medication and that it might take you more or less time for symptom relief. Talk to your gastroenterologist or primary care provider if you're concerned with how well dicyclomine is working for you.
It takes about 10 hours for most of the dicyclomine to leave your body after a single dose. This time frame is estimated based on the half-life of dicyclomine. If you're having side effects from the medication, they might last as long as it takes for the medication to clear your system.
Maybe. A study showed that dicyclomine lessened the number of reflux episodes in a group of 15 people with gastroesophageal reflux disease (GERD). But we need more research done to know whether this medication is beneficial if you have both GERD and IBS. Ask your primary care provider or gastroenterologist if you have GERD and IBS to see what suggestions they have to help relieve your acid reflux. They might recommend proton pump inhibitors or histamine-2 antagonists. Don't take antacids, though, because they can affect how well dicyclomine works for you.
Yes, dicyclomine should help with diarrhea that's caused by irritable bowel syndrome (IBS). The medication relaxes the muscles in the stomach and intestines, which helps slow down gut movement. This helps lessen the feeling of needing to go to the bathroom. Dicyclomine also can help with gas and bloating. But be sure to speak with your primary care provider or gastroenterologist if you're having diarrhea, gas, or bloating that's not getting better after you start taking dicyclomine. There might be other options to help relieve these symptoms.
Yes, it's possible for dicyclomine to make you sleepy. In clinical studies, about 9% of people who took the medication reported sleepiness. Contact your primary care provider or prescriber if you're too tired to the point where it's affecting your ability to go about your day. They might consider lowering your dicyclomine dose or switching you to another medication.
It's recommended to avoid or limit alcohol while you're taking dicyclomine. Alcohol can make dicyclomine side effects like sleepiness and dizziness worse. In addition, alcohol might make certain symptoms of IBS, like nausea and stomach upset, flare up. Talk to your healthcare professional about your drinking habits and whether dicyclomine is appropriate for you.
There are a few medications that you might want to avoid taking with dicyclomine because of drug interactions. You shouldn't take other anticholinergic medications with dicyclomine; otherwise, your risk for side effects is greater. Additionally, dicyclomine can have the opposite effects as metoclopramide (Reglan) and glaucoma medications. This means that dicyclomine can make these medications work less well for you. Let your gastroenterologist, primary care provider, and pharmacist know about all the medications you take so they can make sure they're safe to take with dicyclomine.
Dicyclomine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Let your care team know if you have heart problems, such as heart failure, past heart attacks, high blood pressure, or other medical conditions that cause your heart to beat faster than usual. It's possible for dicyclomine to cause your heart rate to go up, which can worsen certain heart conditions. Tell your care team if you notice a change in your heart rate or if you feel your heart pounding or racing.
Dicyclomine can sometimes cause changes to your mood, thoughts, or ability to think. It can cause symptoms such as confusion or memory loss. It can also lead to feelings of distress, seeing or hearing things that aren't really there (hallucinations), or extreme happiness (euphoria). Typically, these symptoms go away within 12 to 24 hours after you stop taking dicyclomine. Please let a healthcare professional (HCP) know right away if you experience any changes to your mood, thoughts, or behaviors.
Dicyclomine can cause changes to your autonomic nervous system, also known as the involuntary functions of your body. For example, the muscles of your gut might slow down, which can lead to constipation. Your body might also make less saliva, which can lead to dry mouth. Dicyclomine can also affect other functions, such as your heartbeat or vision.
In addition, you might sweat less, which can make you feel thirstier and put you at risk for heat stroke. Don't take dicyclomine without asking your HCP first if you have a fever because the medication might make it worse.
Let your HCP know if you experience any unusual and bothersome changes to your bodily functions.
Though rare, dicyclomine can cause extreme muscle weakness and possibly paralysis. This is very unlikely if you take dicyclomine as prescribed. But muscle weakness is possible if you take a higher dose of the medication than what your prescriber recommended. Don't take dicyclomine if you have a condition called myasthenia gravis, unless your prescriber says it's safe to do so. Let an HCP know right away if you feel any muscle weakness or difficulty moving your body while you're taking dicyclomine.
Let your HCP know before you take dicyclomine for diarrhea if you've ever had a colostomy (or any similar procedures). Sometimes, diarrhea is a sign that you have a block in your gut, especially if you've had these procedures done. Taking dicyclomine in these situations can be harmful.
Also tell your prescriber if you think you have food poisoning to see whether it's safe for you to take dicyclomine. Taking this medication when you have food poisoning can lead to a very dangerous gut problem called toxic megacolon.
In addition, don't take dicyclomine if you have severe ulcerative colitis. Taking large doses of dicyclomine can slow the gut down to a stop. This can result in serious problems, like severe inflammation and swelling of the colon.
Use dicyclomine with caution if you have prostate problems. This medication can worsen prostate problems and lead to difficulty urinating. Let your HCP know if you have worsening symptoms of your prostate problem or have trouble urinating while you're taking dicyclomine.
The typical starting dose is 20 mg by mouth four times daily. After one week, your prescriber might raise your dose to 40 mg by mouth four times daily.
Dicyclomine is also available as an injection that's given into the muscle for people who can't take the medication by mouth.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Dicyclomine will not be safe for you to take.