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Wixela Inhub Coupon - Wixela Inhub 250mcg/50mcg diskus inhaler

fluticasone / salmeterol

Generic Wixela Inhub
Used for Asthma, COPD
Used for Asthma, COPD

Wixela Inhub is a combination inhaler that contains fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting beta agonist, or LABA). This medication is used as maintenance treatment of chronic obstructive pulmonary disease (COPD) and asthma in adults and children. It's inhaled by mouth twice daily. Some of the more common side effects of Wixela Inhub (fluticasone / salmeterol) include upper respiratory tract infections, sore throat, and headaches. Wixela Inhub is the generic version of Advair Diskus.

Last reviewed on December 19, 2023
basics-icon

What is Wixela Inhub (fluticasone / salmeterol)?

What is Wixela Inhub (fluticasone / salmeterol) used for?

  • Maintenance treatment of asthma

  • Maintenance treatment of COPD - Wixela Inhub 250/50 only

How Wixela Inhub (fluticasone / salmeterol) works

Wixela Inhub (fluticasone / salmeterol) is a combination of two medications that work together to help treat asthma and COPD symptoms.

  • Fluticasone is an inhaled corticosteroid. The exact way that it works to treat asthma isn't well-understood. But it's thought to work directly in your lungs to lower inflammation and swelling, thus making it easier for you to breathe.

  • Salmeterol is a long-acting beta agonist. It works by relaxing the muscles in your lungs to open up your airways, making it easier to breathe.

Are you looking for information on AirDuo (fluticasone / salmeterol) or Advair (fluticasone / salmeterol) instead?

Drug Facts

Common BrandsWixela Inhub
Drug ClassICS / LABA combo
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Wixela Inhub (fluticasone / salmeterol)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Upper respiratory infection (up to 27%)
  • Sore throat (up to 13%)
  • Headache (up to 13%)
  • Bronchitis (up to 8%)
  • Cough (up to 6%)
  • Nausea and vomiting (up to 6%)
  • Hoarseness and changes in voice (up to 5%)
  • Sinus infection (up to 5%)

Other Side Effects

  • Dizziness
  • Oral thrush (fungal infection in the mouth)
  • Stomach pain or discomfort
  • Diarrhea
  • Muscle pain
Note: Side effects listed were reported by adults and children ages 12 years and older.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, swelling of your face, lips, or tongue, difficulty breathing
  • Sudden narrowing of your airways: difficulty breathing, wheezing, chest pain or tightness, cough
  • Heart problems: dizziness, fatigue, tremor, nausea, rapid heartbeat, weakness, or difficulty sleeping

Source: DailyMed

More on Wixela Inhub (fluticasone / salmeterol) side effects

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Flu-like symptoms—fever, chills, muscle pain, cough, headache, fatigue
  • Heart rhythm changes—fast or irregular heartbeat, dizziness, feeling faint or lightheaded, chest pain, trouble breathing
  • Increase in blood pressure
  • Low adrenal gland function—nausea, vomiting, loss of appetite, unusual weakness or fatigue, dizziness
  • Muscle pain or cramps
  • Pain, tingling, or numbness in the hands or feet
  • Sinus pain or pressure around the face or forehead
  • Thrush—white patches in the mouth
  • Wheezing or trouble breathing that is worse after use

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Wixela Inhub (fluticasone / salmeterol)

thumbs-up

Pros

Works well to lower the risk of asthma or COPD symptoms

Combines two medications into a single inhaler for convenience

Can be used in children as young as 4 years old with asthma

thumbs-down

Cons

Not a rescue inhaler for treating sudden trouble breathing

Needs to be used twice per day

Can cause fungal infections (thrush) in your mouth and throat

Not a good choice for people allergic to lactose

pharmacist-tips

Pharmacist tips for Wixela Inhub (fluticasone / salmeterol)

pharmacist
  • Use Wixela Inhub (fluticasone / salmeterol) twice daily at the same times every day. This medication works best if it's taken regularly every day.

    • Make sure to rinse your mouth with water and spit after each time you use Wixela Inhub (fluticasone / salmeterol). This helps prevent fungal infections in your mouth and throat (thrush).

      • If you have sudden trouble breathing during a COPD or asthma attack, use your rescue inhaler. Wixela Inhub (fluticasone / salmeterol) won't treat an asthma attack as it's happening.

        • Call your provider if your breathing or peak flow meter results worsen. Also contact your provider if you're using your rescue inhaler more often than usual. These could be signs that your Wixela Inhub (fluticasone / salmeterol) dose is too low, or you need another long-acting medication to help manage your asthma.

          • Don't start any new medications while you're taking Wixela Inhub (fluticasone / salmeterol) without asking your provider or pharmacist first. Wixela Inhub (fluticasone / salmeterol) can interact with other medications, such as blood pressure medications (e.g., beta blockers), tricyclic antidepressants, and certain water pills (diuretics). Your providers can check for interactions to make sure your medications are safe to take.

            • Store Wixela Inhub (fluticasone / salmeterol) at room temperature in a dry place away from heat or sunlight. Keep unused inhalers in the original foil pouch.

              Tips for using Wixela Inhub (fluticasone / salmeterol):

              • Make sure you know how to use the Wixela Inhub (fluticasone / salmeterol) inhaler. Ask your provider or pharmacist if you have any questions.

                • Let your provider know if you're severely allergic to milk proteins because Wixela Inhub (fluticasone / salmeterol) contains lactose.

                  • After removing the Wixela Inhub (fluticasone / salmeterol) inhaler from the foil pouch, it's good for 1 month. Write the expiration ("use by") date on the first blank line on the inhaler.

                    • There's a dose counter on the front face of the Wixela Inhub (fluticasone / salmeterol) inhaler. It should say "60" for a new inhaler. Use this counter to keep track of when you need to get a refill.

                      • You don't need to prime or shake the Wixela Inhub (fluticasone / salmeterol) inhaler before using it.

                        • When you're ready to take your dose, open your inhaler and push down on the yellow lever until it clicks. Hold the Wixela Inhub (fluticasone / salmeterol) inhaler in a vertical position. Then, breathe out as long as you can.

                          • To inhale, place your lips firmly around the mouthpiece and take a fast and deep breath. Try to hold your breath for up to 10 seconds or for as long as you comfortably can so that the medication can reach deep into your lungs. Then, rinse and spit with water.

                            • Don't wash the Wixela Inhub (fluticasone / salmeterol) inhaler. Instead, clean the mouthpiece every once in a while by wiping it with a dry cloth. Don't get water or moisture on or near the inhaler. Moisture can make the dry powder medication clump together and clog the inhaler.

                              faqs

                              Frequently asked questions about Wixela Inhub (fluticasone / salmeterol)

                              Is Wixela Inhub (fluticasone / salmeterol) a steroid?
                              Yes, one of the active ingredients in Wixela Inhub, fluticasone, is a steroid that lowers inflammation in the lungs. The other active ingredient, salmeterol, is a long-acting beta agonist that keeps your airways open. Both medications work together to make it easier for you to breathe.
                              Is Wixela the same as Advair?
                              Wixela Inhub (fluticasone / salmeterol) is the generic version of Advair Diskus (fluticasone / salmeterol). Studies comparing both medications showed they work just as well as each other (therapeutically equivalent). But these two devices look slightly different. For example, Wixela Inhub is held in a vertical position, whereas Advair Diskus needs to be held horizontally, like a hamburger. If you have more questions about either inhaler, talk with your provider.
                              Does Wixela Inhub (fluticasone / salmeterol) cause weight gain?
                              Weight gain was rarely reported by people who used Wixela Inhub (fluticasone / salmeterol) during clinical studies. In general, corticosteroids (like fluticasone) can cause weight gain, especially if they're taken by mouth and over a longer period of time. But since the fluticasone in Wixela Inhub is inhaled, it's less likely to cause weight gain compared to oral steroids. Talk with your provider if you're concerned about Wixela Inhub and weight gain.
                              Does Wixela Inhub (fluticasone / salmeterol) raise blood pressure?
                              Salmeterol, one of the medications in Wixela Inhub, can raise your blood pressure and heart rate. But it's very unlikely for you to experience these side effects if you're using Wixela Inhub (fluticasone / salmeterol) at the recommended dose. If you already have high blood pressure, let your provider know. They might ask you to check your blood pressure more often after you start Wixela Inhub (fluticasone / salmeterol).
                              How long does it take for Wixela Inhub (fluticasone / salmeterol) to work?
                              Your breathing might improve within 30 minutes after a dose of Wixela Inhub (fluticasone / salmeterol). But it can take about 1 week or longer to get the maximum benefit from the medication. If you still don't notice improvement to your symptoms after using Wixela Inhub (fluticasone / salmeterol) for 2 weeks, talk to your provider. They might switch you to a higher strength of the inhaler or start you on other breathing medications.
                              How long does Wixela Inhub (fluticasone / salmeterol) stay in your system?
                              It can take almost 2 days for most of Wixela Inhub (fluticasone / salmeterol) to leave your body after a dose. This time frame is estimated based on the half-life of Wixela Inhub (fluticasone / salmeterol). But keep in mind that in order for Wixela Inhub (fluticasone / salmeterol) to work well to control your symptoms, you need to take this medication twice daily, about 12 hours apart.
                              Can you use Wixela Inhub (fluticasone / salmeterol) and albuterol (Ventolin) together?
                              If you have a sudden asthma attack or COPD exacerbation while already using Wixela Inhub (fluticasone / salmeterol), you can use albuterol (Ventolin) as a rescue inhaler for immediate relief. But if you're reaching for your rescue inhaler more often than usual, let your provider know. They might need to make changes to your breathing medications or Wixela Inhub (fluticasone / salmeterol) dose to better control your symptoms.
                              Can you use Wixela Inhub (fluticasone / salmeterol) and Spiriva (tiotropium) together?
                              Ask your provider if it's appropriate for you to use Wixela Inhub (fluticasone / salmeterol) and Spiriva (tiotropium) together. Both are long-acting medications (maintenance) used to control COPD or asthma, but they don't work in the same way. Wixela Inhub is a combination of an inhaled corticosteroid (ICS) and a long-acting beta agonist (LABA), whereas Spiriva only contains a long-acting muscarinic antagonist (LAMA). Typically, your provider will first ask you to try Wixela Inhub (or a similar combination inhaler with ICS and LABA). But if your symptoms still aren't well-controlled, they might consider adding a LAMA, like Spiriva.
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                              What are the risks and warnings for Wixela Inhub (fluticasone / salmeterol)?

                              Wixela Inhub (fluticasone / salmeterol) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                              risk-warning

                              Not for use in asthma attack or for worsening breathing

                              Don't use Wixela Inhub (fluticasone / salmeterol) if you're experiencing sudden trouble breathing because this medication won't provide immediate relief. Use a rescue inhaler, such as albuterol (Ventolin HFA), if you have breathing problems.

                              If you're using your rescue inhaler more often than usual, let your provider know because this could be a sign that your condition is getting worse. Don't use more doses Wixela Inhub (fluticasone / salmeterol) than recommended because this won't improve your breathing. Rather, this can raise your risk for serious side effects, such as heart problems, tremors, and dizziness.

                              risk-warning

                              Fungal infection in the mouth

                              • Risk factor: Not rinsing and spitting after using Wixela Inhub (fluticasone / salmeterol) | Weakened immune system from medical conditions or medications

                                Wixela Inub includes a steroid medication (fluticasone). When inhaled, it can cause a fungal infection in your mouth and throat called thrush. To lower your risk for thrush, rinse your mouth with water and spit after each inhalation of Wixela Inhub (fluticasone / salmeterol). If you develop thrush, your provider might prescribe you a medication to treat this condition and ask you to temporarily stop using Wixela Inhub (fluticasone / salmeterol). Let your provider know if you notice symptoms of thrush, such as white patches in your mouth, cotton-like feeling in your mouth, pain while eating or swallowing, or loss of taste.

                                risk-warning

                                Narrowing of your airways (bronchospasm)

                                Inhaled medications, including Wixela Inhub (fluticasone / salmeterol), can sometimes cause a muscle spasm in your lungs. This can lead to difficulty breathing, wheezing, cough, and chest discomfort. If you have a hard time breathing after inhaling Wixela Inhub (fluticasone / salmeterol), use your rescue inhaler and get medical attention right away.

                                risk-warning

                                Higher risk of infections

                                Like all corticosteroid-containing medications, Wixela Inhub (fluticasone / salmeterol) can weaken your immune system and raise your risk for infections, including upper respiratory infections and pneumonia. Your risk for infections is higher if you're also taking other medications that weaken your immune system. If you're currently being treated for a serious infection, such as tuberculosis, let your provider know. They might need to consider a different medication for your condition until you get better. Let your provider know right away if you have symptoms of infections, such as fever, chills, body aches.

                                risk-warning

                                Altered stress hormone levels

                                • Risk factors: Using Wixela Inhub (fluticasone / salmeterol) for a long time | Using too much Wixela Inhub (fluticasone / salmeterol)

                                  Use Wixela Inhub (fluticasone / salmeterol) only as directed. Don't use more than the maximum number of inhalations each day. Using more doses of Wixela Inhub (fluticasone / salmeterol) than recommended can cause more steroid to be absorbed into the body and you might experience symptoms such as higher blood sugar or blood pressure.

                                  On the other hand, if you're transitioning to Wixela Inhub (fluticasone / salmeterol) from oral steroids, you might experience symptoms of low steroid hormone, such as stomach pain, loss of appetite, and nausea. When you transition to Wixela Inhub (fluticasone / salmeterol), your provider will work with you to lower your dose of oral steroids slowly over time to prevent these side effects.

                                  risk-warning

                                  Delayed growth in children

                                  Children who use inhaled steroids, like Wixela Inhub (fluticasone / salmeterol), might experience a delay in growth. To lower the risk of growth problems, your child's provider will only prescribe the lowest dose needed to help their condition. The provider will check your child's growth regularly while they're receiving this medication. If you're concerned about how Wixela Inhub (fluticasone / salmeterol) might affect your child's growth, discuss with your child's provider to see if this medication is right for them.

                                  risk-warning

                                  Eye and vision problems

                                  • Risk factors: History of glaucoma or cataracts

                                    Though rare, people using inhaled steroids over a long period of time have reported having higher pressure in the eyes, glaucoma, and cataracts. Talk to your eye provider before using Wixela Inhub (fluticasone / salmeterol) if you have glaucoma or cataracts because they might ask you to come in more often for eye exams. Also speak with them if you notice any changes to your vision while using the medication.

                                    risk-warning

                                    Heart problems

                                    • Risk factors: High blood pressure | Heart failure | Heart rate or rhythm problems | Using more Wixela Inhub (fluticasone / salmeterol) than recommended

                                      The salmeterol in Wixela Inhub might cause changes in your blood pressure, heart rate, and heart rhythm. But these side effects are typically unlikely to happen if you're taking the recommended dose of Wixela Inhub (fluticasone / salmeterol). Your provider might ask you to regularly check your blood pressure and heart rate at home if you have high blood pressure or other heart problems. Don't use Wixela Inhub (fluticasone / salmeterol) more often than recommended. If you find that you need to use Wixela Inhub (fluticasone / salmeterol) more often, let your providers know so they can see if you need any changes to your treatment plan. Tell your provider if you have dizziness, fatigue, tremor, rapid heartbeat, or weakness after you use Wixela Inhub (fluticasone / salmeterol).

                                      risk-warning

                                      Low potassium levels in the blood

                                      • Risk factors: Using Wixela Inhub (fluticasone / salmeterol) too much

                                        Wixela Inhub (fluticasone / salmeterol) can cause the potassium levels in your blood to drop too low. In most cases, this happens if you use more Wixela Inhub (fluticasone / salmeterol) than recommended. Drops in blood potassium levels are typically mild and your levels should go back to usual with time. Sometimes, low potassium can cause tiredness, weakness, muscle cramps, a racing heart, and a "pins and needles" feeling in your hands and feet. Tell your provider if you experience any of these symptoms while you're using Wixela Inhub (fluticasone / salmeterol). Also let your provider know if you need to use Wixela Inhub (fluticasone / salmeterol) more often than instructed. Your treatment plan might need to be adjusted to better control your symptoms.

                                        risk-warning

                                        Allergic reactions

                                        Allergic reactions to Wixela Inhub (fluticasone / salmeterol) are possible. These reactions can include life-threatening facial swelling, shock, and anaphylaxis (closing of the throat). Get medical attention right away if you notice hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing after you use Wixela Inhub (fluticasone / salmeterol).

                                        dosage

                                        Wixela Inhub (fluticasone / salmeterol) dosage forms

                                        The average cost for 1 diskus inhaler of 250mcg/50mcg of Wixela Inhub (fluticasone / salmeterol) is $56.66 with a free GoodRx coupon. This is 81.64% off the average retail price of $308.64.
                                        diskus inhaler
                                        Diskus inhaler
                                        DosageQuantityPrice as low asPrice per unit
                                        100mcg/50mcg1 diskus inhaler$56.66$56.66
                                        250mcg/50mcg1 diskus inhaler$56.66$56.66
                                        500mcg/50mcg1 diskus inhaler$97.64$97.64

                                        Typical dosing for Wixela Inhub (fluticasone / salmeterol)

                                        Wixela Inhub is available in 3 different strengths: 100 mcg/50 mcg (fluticasone / salmeterol), 250 mcg/50 mcg (fluticasone / salmeterol), and 500 mcg/50 mcg (fluticasone / salmeterol).

                                        • Asthma:

                                          • Adults and children ages 12 years and older: Your provider will determine your dose based on how severe your asthma is and what other medications you've taken. The typical dose is 1 inhalation by mouth twice daily.

                                          • Children ages 4 to 11 years old: The typical dose is 1 inhalation of Wixela Inhub 100 mcg/50 mcg (fluticasone / salmeterol) by mouth twice daily.

                                        • COPD:

                                          • The typical dose is 1 inhalation of Wixela Inhub 250 mcg/50 mcg (fluticasone / salmeterol) by mouth twice daily.

                                        drug-cost

                                        How much does Wixela Inhub (fluticasone / salmeterol) cost?

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                                        contraindications-icon

                                        Wixela Inhub (fluticasone / salmeterol) contraindications

                                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Wixela Inhub (fluticasone / salmeterol) will not be safe for you to take.
                                        • Treatment of sudden, severe asthma attack

                                        • Allergy to fluticasone (inhaled corticosteroid) or salmeterol (long-acting beta agonist)

                                        • Serious lactose allergy

                                        alternatives

                                        What are alternatives to Wixela Inhub (fluticasone / salmeterol)?

                                        There are a number of medications that your doctor can prescribe in place of Wixela Inhub (fluticasone / salmeterol). Compare a few possible alternatives below.
                                        Wixela Inhub (fluticasone / salmeterol)
                                        Used for:
                                        • Maintenance treatment of asthma

                                        • Maintenance treatment of COPD - Wixela Inhub 250/50 only

                                        $56.66 Lowest GoodRx priceView Prices
                                        Used for:
                                        • Maintenance treatment of asthma

                                        • Maintenance treatment of COPD

                                        $233.52 Lowest GoodRx priceView Prices
                                        latest news

                                        What is the latest news about Wixela Inhub (fluticasone / salmeterol)?

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                                        This medicine is White Diskus Inhaler.white - Wixela Inhub 250mcg-50mcg / actuation Powder for Inhalation

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                                        References

                                        Best studies we found

                                        American Lung Association. (2023). How to use a Diskus asthma inhaler.

                                        American Lung Association. (2023). How to use an Inhub inhaler.

                                        American Lung Association. (2023). Measuring your peak flow rate.

                                        View All References (7)

                                        Donohue, J. F., et al. (2021). Wixela Inhub: A generic equivalent treatment option for patients with asthma or COPD. Pulmonary Therapy.

                                        Guhan, A. R., et al. (2000). Systemic effects of formoterol and salmeterol: A dose-response comparison in healthy subjects. Thorax.

                                        MedlinePlus. (2016). Cushing’s syndrome.

                                        Mylan Pharmaceuticals Inc. (2022). Wixela Inhub- fluticasone propionate and salmeterol powder [package insert]. DailyMed.

                                        National Institute of Diabetes and Digestive and Kidney Diseases. (2018). Symptoms & causes of adrenal insufficiency & Addison's disease.

                                        Ng, D., et al. (2020). Clinical bioequivalence of Wixela Inhub and Advair Diskus in adults with asthma. Journal of Aerosol Medicine and Pulmonary Drug Delivery.

                                        Viatris Inc. (2021). How to use Wixela Inhub®.

                                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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