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Rituxan
Used for Leukemia, Non-Hodgkin Lymphoma, Rheumatoid Arthritis
Used for Leukemia, Non-Hodgkin Lymphoma, Rheumatoid Arthritis
Rituxan (rituximab) is a monoclonal antibody. It treats certain types of blood cancers (e.g., non-Hodgkin lymphoma) and autoimmune conditions (e.g., rheumatoid arthritis) by targeting specific immune cells. Rituxan (rituximab) is given as an infusion through the vein (IV), typically at an infusion center. Your oncologist will give you premedications before each dose to lower the risk of serious infusion-related reactions. Other possible side effects of this medication include rash and weakness. Rituxan (rituximab) is available as many different brands (or biosimilars), but they don't all treat the same conditions.
What is Rituxan (rituximab)?
What is Rituxan (rituximab) used for?
- Certain types of CD20-positive non-Hodgkin’s lymphoma (NHL) in adults and children ages 6 months and older
- CD20-positive chronic lymphocytic leukemia (CLL) in adults
Autoimmune conditions
- Moderate to severe rheumatoid arthritis (RA) in adults
- Granulomatosis with polyangitis (GPA) and microscopic polyangitis (MPA) in adults and children ages 2 years and older
- Moderate to severe pemphigus vulgaris in adults
How Rituxan (rituximab) works
Rituxan (rituximab) is a monoclonal antibody. It targets specific immune cells called B cells that can be involved in a range of different health conditions. For example, B cells sometimes turn into cancer cells. Other times, they become overly active and cause autoimmune conditions.
Rituxan (rituximab) works by attaching a specific protein on the B cells called CD20. When it does so, it signals to the body to attack and kill that cell. As a result, these abnormal or overly active B cells can't grow, spread, or work as well.
Drug facts
| Common Brands | Rituxan |
|---|---|
| Drug Class | Anti-CD20 monoclonal antibody |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
More on Rituxan (rituximab) essentials
Side effects of Rituxan (rituximab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Fever (53%)
- Lower white blood cell counts (up to 48%)
- Chills (33%)
- Infection (31%)
- Weakness (26%)
- Nausea (23%)
- Headache (19%)
- Night sweats (15%)
- Rash (15%)
Please note: Side effects listed were reported by people who took Rituxan (rituximab) alone for NHL in clinical studies.
Less Common Side Effects
- Stomach pain
- General pain
- Itching
- Cough
- Runny nose
- Swelling
Rituxan (rituximab) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Infusion-related reaction: swelling, trouble breathing, chest pain, low blood pressure, red skin
- Serious skin reaction: painful blisters, skin wounds, peeling skin, fever, sore throat, body aches
- Tears in the gut: sudden and severe stomach pain, fever, chills, and nausea or vomiting that won’t go away
- Infection: fever, chills, cough, muscle aches, very fast heartbeat, severe tiredness
- Tumor lysis syndrome: seizures, hallucinations, nausea, tiredness, no appetite, dark-colored urine, muscle cramps, numbness
- Serious heart problems: tiredness, weakness, dizziness, feeling faint, trouble breathing, pressure on the chest, pounding heart, irregular heart beat, sweating, feeling anxious, nausea
More on Rituxan (rituximab) side effects
The following Rituxan (rituximab) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
More common
Black, tarry stools
bleeding gums
bloating or swelling of the face, arms, hands, lower legs, or feet
blood in the urine or stools
blurred vision
body aches or pain
burning or stinging of the skin
chills
confusion
difficulty with breathing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
drowsiness
ear congestion
flushed, dry skin
fruit-like breath odor
headache
increased hunger
increased thirst
increased urination
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
lower back or side pain
nervousness
noisy breathing
pain or tenderness around the eyes and cheekbones
painful cold sores or blisters on the lips, nose, eyes, or genitals
painful or difficult urination
pale skin
pinpoint red spots on the skin
pounding in the ears
seizures
slow or fast heartbeat
sores, ulcers, or white spots in the mouth or on the lips
stomach pain
stuffy or runny nose
sweating
swelling of the tongue or throat
swollen glands
tightness of the chest
tingling of the hands or feet
troubled breathing with exertion
unusual bleeding or bruising
unusual tiredness or weakness
unusual weight gain or loss
vomiting
Less common
Blistering, peeling, or loosening of the skin
blisters on the trunk, scalp, or other areas
burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feeling
decreased frequency and amount of urine
difficulty with moving
discouragement
feeling sad or empty
irregular heartbeat
irritability
joint or muscle pain
loss of appetite
loss of interest or pleasure
lump or growth on the skin
muscle cramp, pain, or stiffness
numbness or tingling in the hands, feet, or lips
painful blisters on the trunk of the body
pain or redness at the injection site
pain, swelling, or redness in the joints
pounding or irregular heartbeat or pulse
red skin lesions, often with a purple center
red, itchy lining of the eye
redness of the face, neck, arms, and occasionally, upper chest
stabbing pain
trouble concentrating
trouble sleeping
Incidence not known
Blue-yellow color blindness
blurred vision or other change in vision
burning or stinging of the skin
decreased vision
dilated neck veins
extreme tiredness or weakness
eye pain, tearing
feeling of discomfort, illness, or weakness
irregular breathing
nosebleed
painful cold sores or blisters on the lips, nose, eyes, or genitals
sensitivity of the eye to light
severe abdominal or stomach pain
severe vomiting, sometimes with blood
sores, welts, or blisters
stomach cramps
swelling, stiffness, redness, or warmth around many joints
swollen lymph glands
vision loss
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Agitation or anxiety
bone pain
burning, dry, or itching eyes
change in taste
discharge, excessive tearing
excessive muscle tone
feeling of constant movement of self or surroundings
increase in body movements
lightheadedness
muscle tension
redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
sensation of spinning
sleepiness
swelling of the stomach
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Rituxan (rituximab)
Pros
- Works in a more targeted, specific way than chemotherapy
- Might only need a dose once every 6 months for certain conditions
- Doesn’t typically cause hair loss
Cons
- Can cause serious infusion-related reactions
- Each infusion can last over 3 hours, so can be inconvenient
- Higher risk of infections can last a year after your last dose (sometimes longer)
Pharmacist tips for Rituxan (rituximab)
- How often you need a Rituxan (rituximab) infusion depends on your medical condition and how your body responds to the medication. Make sure you know when your infusions are scheduled and mark the dates on your calendar so you don’t miss a dose. There are also several apps for your phone that can help you keep track.
- Each Rituxan (rituximab) infusion appointment can last almost the full day because of the time it takes to receive pre-medications and Rituxan (rituximab) infusion. Please plan accordingly for this time. Make sure you dress comfortably, bring water and food, and have something to help you pass the time, such as a book or music.
- Your provider will give you premedications, such as steroids, acetaminophen (Tylenol), and antihistamines, before each Rituxan (rituximab) infusion. These medications can help lower the risk of an infusion-related reaction, which can be very serious.
- To lower your risk of infusion reactions from Rituxan (rituximab), your provider will infuse the medication slowly during the first dose. Typically, your first infusion can last 4 to 6 hours, or longer. If you’re able to tolerate this dose without any problems, your provider might be able to give your Rituxan (rituximab) infusions at a faster rate in the future (around 3 to 4 hours).
- Check your temperature regularly, such as once a day, when you’re receiving Rituxan (rituximab) treatment. Call your provider immediately if your temperature is 100.4 degrees Fahrenheit or higher; this means you have a fever. It’s important for your provider to know if you get sick, and sometimes a fever might be the only sign that you’re sick.
- Rituxan (rituximab) can raise your risk of infection, even up to 1-2 years after your last dose. Depending on what condition you’re taking it for, your provider might prescribe antibiotics or antiviral medications for you to take to prevent serious infections.
- Nausea and vomiting aren’t common for people taking Rituxan (rituximab) without chemotherapy. But, if you do have nausea or vomiting, contact your provider. There are several antiemetic medications such as ondansetron (Zofran) or promethazine (Phenergan) your provider might prescribe to help manage it.
- We don’t know if Rituxan (rituximab) passes into human milk. But, because of the risks to a nursing infant, you shouldn’t breastfeed while taking Rituxan (rituximab) and for 6 months after the last dose.
More on Rituxan (rituximab) tips
Risks and warnings for Rituxan (rituximab)
Rituxan (rituximab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Infusion-related reactions
People taking Rituxan (rituximab) might experience infusion-related reactions. These reactions are most common within the first two hours of the first infusion. Symptoms include rash and red skin, swelling, trouble breathing, chest pain, irregular heartbeat, and low blood pressure. Sometimes, these reactions can be very serious and cause throat swelling, anaphylaxis, or heart attacks. This can be life threatening.
You’ll take several medications before each treatment, such as acetaminophen (Tylenol) and diphenhydramine (Benadryl) to help prevent a reaction. Your nurse will watch you closely during your first treatment, but you should tell them right away if you experience any symptoms during your treatment. If you have a severe reaction to Rituxan (rituximab), you might not be able to continue taking the medication.
Serious skin reactions
Some people taking Rituxan (rituximab) have experienced serious and sometimes life-threatening skin problems, such as Stevens-Johnson syndrome (SJS), paraneoplastic pemphigus, toxic epidermal necrolysis (TEN), and others. Tell your provider right away if you develop painful blisters, skin wounds, peeling skin, or fever as these are signs of a serious skin reaction that need immediate medical attention.
Hepatitis B reactivation
- Risk factors: History of hepatitis B viral infection
Some people who had hepatitis B in the past experienced a new infection (hepatitis B reactivation) after starting Rituxan (rituximab). Your provider will test you for hepatitis B virus before you start taking Rituxan (rituximab). If you test positive, you might need treatment for hepatitis B before you start taking Rituxan (rituximab). If you develop a hepatitis B infection during treatment, you’ll need to stop taking Rituxan (rituximab) while your provider treats it. Let your provider know right away if you experience symptoms of an active hepatitis B infection, such as fever, tiredness, or yellowing of the skin.
Progressive multifocal leukoencephalopathy
- Risk factors: Taking Rituxan (rituximab) with chemotherapy | Taking Rituxan (rituximab) for stem cell transplant
Rarely, people taking Rituxan (rituximab) have developed a serious brain condition called progressive multifocal leukoencephalopathy (PML). PML is caused by a virus called JC virus and can lead to brain damage. Let your provider know if you’ve PML symptoms while taking Rituxan (rituximab), such as weakness, clumsiness, difficulty speaking, and difficulty walking.
Tumor lysis syndrome
- Risk factors: People taking Rituxan (rituximab) for lymphoma
Some people taking Rituxan (rituximab) to treat cancer developed a complication called tumor lysis syndrome (TLS) that can cause damage in multiple areas of the body. TLS happens when cancer cells are destroyed and release what’s inside them, such as potassium and uric acid, into your blood. TLS is most common during the first treatment cycle, and symptoms can appear within 24 hours of the Rituxan (rituximab) infusion. Your provider will closely monitor you with lab tests, and might give you extra fluids or a medication such as allopurinol (Zyloprim) to prevent TLS. Let your provider know if you experience symptoms of TLS, such as nausea, tiredness, and no appetite.
Serious infections
- Risk factors: Taking Rituxan (rituximab) with chemotherapy
People who take Rituxan (rituximab) can develop serious infections, including viral, bacterial, and fungal infections. If you do get sick, you might need to pause taking Rituxan (rituximab) and start taking other medications to treat the infection. If you develop a serious infection you might have to stop taking Rituxan (rituximab) altogether. Contact your provider if you develop signs and symptoms of an infection such as fever, chills, muscle aches, or severe tiredness or weakness.
Serious heart problems
Serious heart problems have happened during Rituxan (rituximab) infusions, including heart rhythm changes such as ventricular fibrillation, and heart attacks. If your heart rhythm changes during your treatment, your provider might recommend closer monitoring with a test called an electrocardiogram (EKG) during your infusions. If you develop serious heart problems during treatment, your provider might stop your Rituxan (rituximab) infusion.
Kidney problems
Risk factors: Tumor lysis syndrome | Taking cisplatin Some people taking Rituxan (rituximab) experienced kidney problems. This was more common in people who developed tumor lysis syndrome or who were taking Rituxan (rituximab) together with a chemotherapy medication called cisplatin. Your provider will monitor your kidney health with a blood test while you’re taking Rituxan (rituximab). Let your provider know if you have trouble making urine, notice swelling in your hands and feet; these might be symptoms of kidney problems.
Gut blockage and tears
Some people have reported stomach pain, intestinal blockage, and tears in the lining of the gut after starting Rituxan (rituximab) with chemotherapy for NHL. For some people, these side effects appeared 2 months after the start of treatment. Contact your provider right away if you have sudden and severe stomach pain, fever, chills, and nausea or vomiting that won’t go away.
Vaccines
Make sure you’re up-to-date with your vaccines before starting Rituxan (rituximab). We don’t know if it’s safe to take live virus vaccines while taking Rituxan (rituximab). You should avoid live vaccines during treatment. And you need to receive any non-live vaccines at least 4 weeks before Rituxan (rituximab) treatment. Talk to your provider before getting any vaccine while you’re taking Rituxan (rituximab), even if it’s an inactivated vaccine.
Harm to unborn baby
Based on data from human pregnancies, Rituxan (rituximab) can cause harm to an unborn baby. If you’re a female who is able to have babies, you should use effective birth control while taking Rituxan (rituximab) and for 12 months after the last dose. Contact your provider right away if you become pregnant while taking Rituxan (rituximab).
Combination treatment for people with autoimmune conditions
Risk factors: People taking Rituxan (rituximab) for autoimmune conditions We don’t know if it’s safe to take other biologic medications or disease-modifying antirheumatic drugs (DMARDs) together with Rituxan (rituximab). Because taking these medications together might raise your risk for infection, your provider will closely monitor you if they recommend a combination treatment.
Rituxan (rituximab) dosage
Typical dosage for Rituxan (rituximab)
Blood cancers
Your provider will determine your dose of Rituxan (rituximab) based on your body surface area (BSA) in m². This medication is typically given by a healthcare provider in a hospital or infusion clinic setting. Your provider might also give you other anticancer medications along with Rituxan (rituximab).
-
Non-Hodgkin’s lymphoma
- Adults: The typical dose is 375 mg/m² given as an intravenous infusion. How often you’ll receive a dose usually ranges from weekly to every 8 weeks, depending on the type of NHL you have and where you are in the treatment process.
- Children: Talk with your child’s provider.
-
Chronic Lymphocytic Leukemia (CLL)
- Adults: The typical dose is to receive one 375 mg/m² intravenous infusion before the start of chemotherapy. Then, your provider will raise your dose to 500 mg/m² infused on Day 1 of a 28-day chemotherapy cycle, for 2 to 6 cycles.
Autoimmune conditions
Your provider might also give you other medications along with Rituxan (rituximab) to treat your condition.
-
RA
- Adults: The typical starting dose is 1,000 mg infused IV for 2 doses, given 2 weeks apart. The typical maintenance dose is 1,000 mg infused once every 4 to 6 months, depending on your condition.
-
GPA and MPA
- Adults: Your provider will determine your dose of Rituxan (rituximab) based on your body surface area (BSA) in m². The typical starting dose is 375 mg/m² given as an intravenous infusion weekly for 4 weeks. The typical maintenance dose is 500 mg given as 2 doses 2 weeks apart, then 500 mg every 6 months.
- Children: Ask your child’s provider.
-
PV
- Adults: The typical starting dose is 1,000 mg infused IV for 2 doses, given 2 weeks apart. The typical maintenance dose is 500 mg infused a year after the starting dose, then once every 6 months.
Interactions between Rituxan (rituximab) and other drugs
Rituxan (rituximab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Rituxan (rituximab). Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Measles Virus Vaccine, Live
- Mumps Virus Vaccine, Live
- Rotavirus Vaccine, Live
- Rubella Virus Vaccine, Live
- Varicella Virus Vaccine, Live
- Zoster Vaccine, Live
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Abatacept
- Adenovirus Vaccine
- Bacillus of Calmette and Guerin Vaccine, Live
- Cholera Vaccine, Live
- Cisplatin
- Dengue Tetravalent Vaccine, Live
- Infliximab
- Influenza Virus Vaccine, Live
- Poliovirus Vaccine, Live
- Smallpox Vaccine
- Tofacitinib
- Typhoid Vaccine, Live
- Yellow Fever Vaccine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Influenza Virus Vaccine (Subvirion)
- Pneumococcal Vaccine Polyvalent
What are alternatives to Rituxan (rituximab)?
There are a number of medications that your doctor can prescribe in place of Rituxan (rituximab). Compare a few possible alternatives below.
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Rituxan (rituximab) images
