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Refissa Coupon - Refissa 20g of 0.05% tube of cream

tretinoin cream

Generic Renova
Used for Facial Wrinkles, Skin Discoloration

Renova is a topical retinoid that contains tretinoin 0.02% cream. Renova (tretinoin) can ease fine facial wrinkles, in addition to the regular use of sunscreen and sun-protective clothing. But it won't help get rid of deep wrinkles or hyperpigmentation from years of sun damage. Renova (tretinoin) is applied to the face once daily in the evening. This medication commonly causes skin irritation and peeling as side effects. Renova is a prescription medication that's brand name only and not available as a generic.

Reviewed by:Last reviewed on July 14, 2024
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What is Renova (tretinoin)?

What is Renova (tretinoin) used for?

How Renova (tretinoin) works

Renova (tretinoin) is a retinoid, which is a form of vitamin A that's naturally in the body and helps the skin renew itself.

When does Renova (tretinoin) start working?Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug facts

Common BrandsRenova, Refissa(brand no longer available)
Drug ClassRetinoic acid derivative
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Renova (tretinoin)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Almost all people who used Renova in clinical studies reported one or more of the following:

  • Burning or stinging
  • Peeling
  • Redness
  • Dry skin
  • Itching

Less Common Side Effects

  • Changes in color of treated skin
When do Renova (tretinoin) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Possible burning or stinging
Possible peeling
Possible redness
Possible dry skin
Possible itching
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Renova (tretinoin) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning, stinging, peeling, redness, or unusual dryness of the skin (severe)

Less common

Dryness, pain, redness, irritation, or peeling at the application site

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, itching, stinging, scaling, or redness of the skin

chapping or slight peeling of the skin (mild)

darkening of the skin

lightening of normal skin color

lightening of treated areas of dark skin

redness of skin (mild)

unusual dryness of skin (mild)

unusually warm skin (mild)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Pros and cons of Renova (tretinoin)

Pros

  • Applied only once a day
  • Only need a small pearl-sized amount to have an effect
  • Can use with other cosmetics or skincare products (must wait at least 1 hour after applying Renova)

Cons

  • Doesn't get rid of deep wrinkles, repair sun-damaged skin, reverse skin aging due to sun damage, or make skin younger
  • Can make you sunburn more easily
  • Not a good choice for females who want to become pregnant or are pregnant
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Pharmacist tips for Renova (tretinoin)

pharmacist
  • You'll need to apply Renova (tretinoin) regularly for at least 3 to 4 months before you see improvement. Once you stop, the improvement may slowly disappear.
  • Wash your hands before and after applying Renova (tretinoin) cream to your face. Avoid getting the cream in your eyes, mouth, ears, or nose. Doing so can cause serious skin irritation because those areas are more sensitive.
  • Gently wash your face with mild soap, pat the skin dry, and wait 20 to 30 minutes before applying Renova (tretinoin).
  • Apply a very small amount (pea-size) of Renova (tretinoin) on your entire face once a day in the evening or at bedtime. Applying more medication won't lead to faster or better results, but can worsen skin reactions.
  • You might feel a mild warmth or slight stinging sensation when you first apply Renova (tretinoin).
  • Renova (tretinoin) should be used as a part of a complete skin care routine that includes avoiding sunlight, using a good sunscreen, and wearing protective clothing. While using this medication, avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear to protect you from the sun.
  • Check with your dermatologist or pharmacist before you take any new medications while also using Renova (tretinoin) because some medications can also make you sensitive to the sunlight.
  • You can use other skincare products or cosmetics after applying Renova (tretinoin). But you must wait at least 1 hour after using Renova before applying those products.
  • Renova (tretinoin) isn't safe to use during pregnancy. Even though it's applied to the skin, a small amount is absorbed into the body and can harm the unborn baby.
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Common questions about Renova (tretinoin)

Renova (tretinoin) is similar to retinol because they're both retinoids; but they're not the same. Retinol is found in topical over-the-counter (OTC) skin care products. Once applied to the skin, retinol becomes retinoic acid and works to treat acne, even out skin discoloration, and provide anti-aging benefits. Renova (tretinoin) is a prescription-strength retinoid that's more potent than OTC retinol.

Yes, Renova contains tretinoin, which is a prescription-strength retinoid. This medication is FDA-approved to help improve the look of fine facial wrinkles.

No, Renova (tretinoin) isn't a steroid. Rather, it's a retinoid, which is a form of vitamin A.

When you use Renova (tretinoin), you won't see improvements in your skin right away. You might notice some effects in 3 to 4 months, but it can take up to 6 months to see noticeable results. If you stop Renova (tretinoin) treatment, the improvement might disappear over time. Renova (tretinoin) hasn't been studied in people for more than 1 year. Therefore, it's not known if Renova (tretinoin) is safe or will continue to work well after 1 year.

Yes. Don't use Renova (tretinoin) beyond its expiration date because it's unclear if it's safe or will still work for you.

People who used Renova (tretinoin) in clinical studies didn't report skin purging as a side effect. Skin purging is a reaction typically seen when retinoids, such as tretinoin, are used to treat acne. A purge is when there's a flare-up of acne for a few weeks at the beginning of treatment, as the medication is working deep within the skin. But because Renova (tretinoin) is used to treat fine facial wrinkles instead of acne, it's possible that Renova (tretinoin) doesn't cause skin purging in the same way as when tretinoin is used for acne. But people who used Renova (tretinoin) did report other types of skin reactions, such as peeling, redness, and dry skin.

Leave Renova (tretinoin) on for at least 1 hour before washing your face. In fact, it's best if you apply this medication at night before you go to bed. Then, you can wash your face and do your usual morning skincare routine the next morning.

Yes, you can use Renova (tretinoin) every night. If your skin becomes dry or flaky after use, your skin care specialist might ask you to use Renova (tretinoin) less often until your skin becomes more used to the medication.

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Risks and warnings for Renova (tretinoin)

Renova (tretinoin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Skin irritation

  • Risk factors: Using other medications or products that irritate the skin | Eczema | Extreme temperatures (hot or cold)

Renova (tretinoin) can cause skin redness, burning, peeling, or swelling. Applying larger amounts than recommended doesn't lead to quicker or better results and actually causes more skin irritation. Be careful using Renova (tretinoin) if you have a condition called eczema, because your skin might already be red, itchy, and irritated. If you have severe skin irritation, let your skin care team know. They might ask you to use less Renova (tretinoin), use it less often, or temporarily or permanently stop this medication, depending on how serious your reaction is.

Renova (tretinoin) can be particularly harmful to sensitive skin areas and should never be applied to the eyes, mouth, or nose.

Sunburns

  • Risk factors: High levels of sun exposure | Having skin that burns easily | Living in a hot climate | Working outdoors

Using Renova (tretinoin) can make your skin more sensitive to both natural sunlight and artificial sunlight from sunlamps. This can cause your skin to burn more easily. Having skin that's more sensitive to light might also raise your risk of early aging of the skin or skin cancer.

It's important to protect your skin from sunlight by finding shade outdoors, using sunscreen when you're outside (even on cloudy days), and wearing sun-protective clothing (like hats). Also avoid using sunlamps. Ask your primary care provider or dermatologist about which SPF (sun protection factor) level of sunscreen will protect you best. Stop using Renova (tretinoin) until your skin fully heals if you get sunburned.

Harm to unborn baby

  • Risk factors: Pregnant | Females who are able to have children

Using Renova (tretinoin) on your skin can harm your unborn baby. Don't use Renova (tretinoin) if you're planning to become or are pregnant. Talk to your healthcare team about a better alternative to lessen fine wrinkles.

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Renova (tretinoin) dosage

The average cost for 1 tube of 20g of 0.05% of Renova (tretinoin) is $72.10 with a free GoodRx coupon. This is 55.21% off the average retail price of $160.98.
tube of creamTube of cream
DosageQuantityPrice as low asPrice per unit
40g of 0.05%1 tube$135.05$135.05
20g of 0.05%1 tube$72.10$72.10

Typical dosage for Renova (tretinoin)

  • Adults: Apply a small, pearl-sized (about ¼ inch or 5 mm) amount of cream to cover the entire affected area lightly once a day in the evening.
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Interactions between Renova (tretinoin) and other drugs

Renova (tretinoin) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Renova (tretinoin). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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What are alternatives to Renova (tretinoin)?

There are a number of medications that your doctor can prescribe in place of Renova (tretinoin). Compare a few possible alternatives below.
Renova (tretinoin)
Used for:
$57.05Lowest GoodRx priceView prices
Used for:

Temporarily improves the appearance of moderate to severe facial lines, including:

  • Frown lines
  • Crow's feet
  • Forehead lines
  • Neck lines
$353.77Lowest GoodRx priceView prices
latest-news-icon

News about Renova (tretinoin)

Adapalene (Differin) and tretinoin (Retin-A) are retinoids that can reduce the appearance of wrinkles. Adapalene may be less irritating than tretinoin.
Adapalene (Differin) vs. Tretinoin (Retin-A) for Wrinkles: 4 Differences to Know About
Adapalene (Differin) and tretinoin (Retin-A) are retinoids that can reduce the appearance of wrinkles. Adapalene may be less irritating than tretinoin.
Wrinkles are common and come with aging or spending too much time in the sun. You can prevent them by using wrinkle treatment like moisturizing, retinoids, and more.
9 Treatments That Work on Wrinkles: Tretinoin, Lasers, and More
Wrinkles are common and come with aging or spending too much time in the sun. You can prevent them by using wrinkle treatment like moisturizing, retinoids, and more.
Compare the effectiveness of adapalene and tretinoin for acne and learn which retinoid could lead you to clearer skin.
Tretinoin vs. Adapalene for Acne: What Are The Differences and Which Works Better?
Compare the effectiveness of adapalene and tretinoin for acne and learn which retinoid could lead you to clearer skin.
Learn about common tretinoin (Retin-A) interactions, including interactions with other topical skin care ingredients like salicylic acid.
4 Tretinoin Interactions to Watch Out For
Learn about common tretinoin (Retin-A) interactions, including interactions with other topical skin care ingredients like salicylic acid.
Tretinoin generic is the same medication as branded Retin-A, but is one better than the other? Here’s how Tretinoin and Retin-A compare.
Tretinoin vs. Retin-A: Is There A Difference Between These Medications?
Tretinoin generic is the same medication as branded Retin-A, but is one better than the other? Here’s how Tretinoin and Retin-A compare.
Retin-A (tretinoin) can start working in 2 weeks, but the full effects can take 12 weeks or longer. Learn more about Retin-A with these FAQs from GoodRx.
How Long Does Retin-A Take to Work? Plus, 4 More FAQs
Retin-A (tretinoin) can start working in 2 weeks, but the full effects can take 12 weeks or longer. Learn more about Retin-A with these FAQs from GoodRx.
Retin-A can be beneficial for acne. Learn more about Retin-A, including the best moisturizer to use with Retin-A, with this guide from GoodRx.
What’s The Best Way to Apply Retin-A? Plus, 5 More Pharmacist Tips
Retin-A can be beneficial for acne. Learn more about Retin-A, including the best moisturizer to use with Retin-A, with this guide from GoodRx.
Tretinoin is a moderately-priced topical medication to treat a range of skin conditions. Here’s what you need to know about how to get tretinoin and how you can save.
How to Get and Save Money on Tretinoin
Tretinoin is a moderately-priced topical medication to treat a range of skin conditions. Here’s what you need to know about how to get tretinoin and how you can save.
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Renova (tretinoin) images

yellow - Refissa 0.05% Topical Cream
This medicine is Yellow Tube Of Cream.yellow - Refissa 0.05% Topical Cream

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References

Best studies we found

Bausch Health US LLC. (2019). Renova- tretinoin cream [package insert]. DailyMed.

Motamedi, M., et al. (2022). A clinician's guide to topical retinoids. Journal of Cutaneous Medicine and Surgery.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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