Key takeaways
Cetirizine (Zyrtec) and Claritin-D (loratadine/pseudoephedrine) are both used to relieve allergy symptoms, but they have some key differences. Cetirizine is a second-generation antihistamine that helps with symptoms like runny nose and itchy eyes and is available in various forms, including tablets and liquids. It is typically taken once a day and is less likely to cause drowsiness compared to first-generation antihistamines like diphenhydramine (Benadryl). On the other hand, Claritin-D combines an antihistamine (loratadine) with a decongestant (pseudoephedrine) to also address nasal and sinus congestion. Claritin-D comes in 12-hour and 24-hour tablets and is taken either once or twice a day. While both medications are available over-the-counter, Claritin-D is kept behind the pharmacy counter due to the pseudoephedrine component, which can raise blood pressure and has potential for misuse. Additionally, Claritin-D is not recommended for children under 12 years old, whereas cetirizine can be used in younger children with specific dosing. Both medications can cause drowsiness, but Claritin-D may also lead to increased heart rate and blood pressure, making it less suitable for people with certain health conditions.
