Key takeaways
Sertraline (Zoloft) and amitriptyline (Elavil) are both used to treat depression, but they belong to different classes of medications. Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI), while amitriptyline is a tricyclic antidepressant (TCA). Sertraline (Zoloft) is also approved for several anxiety disorders, including panic disorder and social anxiety disorder, whereas amitriptyline is often used off-label for nerve pain and migraine prevention. Sertraline (Zoloft) is typically taken once daily and is available in both tablet and liquid forms, while amitriptyline can be taken in divided doses throughout the day or as a single dose at bedtime. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth, whereas amitriptyline often causes sleepiness, weight gain, and dizziness. Both medications can cause withdrawal symptoms if stopped abruptly, but amitriptyline has more interactions with other medications compared to sertraline (Zoloft). Additionally, sertraline (Zoloft) is less likely to cause weight gain compared to other SSRIs, while amitriptyline is known for its higher risk of weight gain.
