Key takeaways
Sertraline (Zoloft) and lorazepam (Ativan) are both medications approved to treat anxiety. Sertraline is a selective serotonin reuptake inhibitor (SSRI) that also treats depression and other mental-health conditions. It works by increasing serotonin levels in the brain and is typically taken once daily. Lorazepam is a benzodiazepine that works by increasing the levels of a chemical called GABA, which helps calm the mind and body. It's typically taken 1 to 3 times daily. Lorazepam typically starts working quickly, but sertraline can take several weeks to improve your symptoms. Unlike sertraline, lorazepam is a controlled substance that carries a risk of misuse and dependence. So it may not be a safe option for those with a history of substance use disorder.
