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Ziac vs. Lopressor HCT

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Ziac (bisoprolol/hydrochlorothiazide) and metoprolol/hydrochlorothiazide are both combination beta blocker medications used to treat high blood pressure, but they have some differences. Ziac combines bisoprolol, a cardioselective beta blocker, with hydrochlorothiazide, a thiazide diuretic. Metoprolol/hydrochlorothiazide combines metoprolol tartrate, another selective beta blocker, with the same diuretic. Ziac is typically taken once daily, while metoprolol/hydrochlorothiazide can be taken once or twice daily with food. Both medications can cause dizziness and tiredness, but Ziac may also cause headaches and diarrhea. Additionally, Lopressor HCT, the brand name for metoprolol/hydrochlorothiazide, is no longer available, but both medications are available as low-cost generics. Both medications should not be stopped suddenly due to the risk of serious heart problems.

Ziac

(bisoprolol / hydrochlorothiazide)

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Metoprolol/hydrochlorothiazide

 

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Summary for Ziac

Prescription only

Ziac, the brand name for bisoprolol/hydrochlorothiazide or bisoprolol/HCTZ, is a combination medication. It's used to treat high blood pressure in adults. It contains two classes of medications: a beta blocker (bisoprolol) and a diuretic (hydrochlorothiazide). It comes as a tablet that's taken by mouth once a day. Some side effects include dizziness and tiredness.

Indications for Ziac

Pros and Cons for Ziac

Pros

  • Only taken once daily
  • Combines two blood pressure medications into one tablet
  • Can take with or without food

Cons

  • Comes in fixed dosage strengths, so it's harder to adjust the doses of the individual ingredients
  • Can make you urinate more often
  • Not a good option for people with a sulfa allergy

Common Side Effects for Ziac

  • Dizziness (5%)
  • Tiredness (5%)
  • Headache (5%)
  • Diarrhea (4%)

Warnings for Ziac

  • Risk of heart problems after stopping Ziac (bisoprolol / hydrochlorothiazide) suddenly
  • Risk of heart failure
  • Changes in fluids and electrolytes in the body
  • Hidden symptoms of low blood sugar
  • Hidden symptoms of overactive thyroid
  • Caution use in people with breathing problems
  • Caution use in people with peripheral artery disease (PAD)
  • Risk of vision problems and glaucoma

Summary for Lopressor HCT

Prescription only

Metoprolol/hydrochlorothiazide is a combination medication that's used to lower blood pressure in adults. It contains a beta blocker (metoprolol tartrate) that slows down the heart and a thiazide diuretic (hydrochlorothiazide) that removes extra fluids through your kidneys. Metoprolol/hydrochlorothiazide is taken by mouth, typically once or twice daily with food. Some of the more common side effects of this medication include dizziness and tiredness. The brand name, Lopressor HCT, is no longer available.

Indications for Lopressor HCT

Pros and Cons for Lopressor HCT

Pros

  • Taken by mouth just once or twice daily
  • Lowers risk of heart attack and stroke
  • Combines 2 medications into 1 pill for convenience

Cons

  • Can make you urinate more often
  • Stopping suddenly can raise risk of chest pain and heart attack
  • Fixed dosing, so not as easy to adjust the dose (compared to taking each medication separately)

Common Side Effects for Lopressor HCT

  • Tiredness
  • Dizziness
  • Weakness
  • Sun sensitivity

Note: Side effects listed are from people who took metoprolol tartrate or hydrochlorothiazide in clinical studies.

Warnings for Lopressor HCT

  • Risk of chest pain and heart attack
  • Heart failure
  • Risk of difficulty breathing
  • Slow heart rate
  • Greater risk during surgery
  • Hiding symptoms of low blood sugar
  • Hiding symptoms of overactive thyroid
  • Fluid, electrolyte, and kidney problems
  • Eye problems
  • Lupus
  • Serious allergic reactions

Prices with our coupons for Ziac vs. Lopressor HCT

Price Card Drug Icon
Bisoprolol/HCTZ90 tablets / 5mg/6.25mg
$35.21$228.50
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Price Card Drug Icon
Metoprolol/HCTZ90 tablets / 50mg/25mg
$32.28$129.57
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