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Zestoretic vs. Hydrochlorothiazide

Zestoretic is a combination blood pressure medication for adults. It contains lisinopril (an angiotensin-converting enzyme (ACE) inhibitor) and hydrochlorothiazide (a thiazide diuretic). It comes as a tablet that's taken by mouth once per day. Your prescriber will determine your dosage based on how high your blood pressure is and if you're taking other blood pressure medications. Some of the more common side effects it can cause include dizziness, headache, and cough. Zestoretic (lisinopril / hydrochlorothiazide) is available as a generic.

• High blood pressure in adults

• Dizziness (8%)
• Headache (5%)
• Cough (4%)
• Extreme tiredness (4%)
• Feeling lightheaded when standing after sitting or lying down (3%)

• Not for use during pregnancy
• Angioedema (swelling)
• Low blood pressure
• Kidney damage
• Changes in electrolyte, blood sugar, and cholesterol levels
• Vision problems
• Lupus

Hydrochlorothiazide is a diuretic or water pill. It helps lower blood pressure. It also helps with swelling from fluid buildup (edema) caused by some health conditions, like heart failure and kidney problems. People of all ages can take hydrochlorothiazide tablets and capsules. But children typically take much smaller, weight-based doses. You typically take your dose by mouth once (sometimes twice) daily, but avoid nighttime dosing so you won't wake up to urinate. Some common side effects are dizziness and urinating more often.

• High blood pressure
• Swelling in the body from fluid buildup (edema)

• Dizziness
• Weakness
• Headache
• Blurry vision
• Low blood pressure
• Change in electrolyte levels

• Low fluid and electrolyte levels in the body
• Possibly higher calcium levels
• Higher blood sugar
• Risk of gout
• Risk of vision problems and glaucoma
• Use with caution in people with kidney problems