Key takeaways
Zestoretic (lisinopril/hydrochlorothiazide) and Diovan HCT (valsartan/hydrochlorothiazide) are both combination medications used to treat high blood pressure. They both contain hydrochlorothiazide, a diuretic (water pill). But their other components are different. Zestoretic contains lisinopril, an ACE inhibitor, while Diovan HCT contains valsartan, an ARB. Both are usually taken once daily and come as generics. Zestoretic is typically started at a dose of 10 mg/12.5 mg once daily, whereas Diovan HCT usually starts at 160 mg/12.5 mg once daily. Common side effects for Zestoretic include dizziness, headache, and cough, while Diovan HCT may cause dizziness and a common cold. Both medications interact with NSAIDs like ibuprofen. Neither medication is safe to use during pregnancy.
