Key takeaways
Zestoretic (lisinopril/hydrochlorothiazide) and carvedilol (Coreg) are both used to treat high blood pressure, but they belong to different medication classes and have different mechanisms of action. Zestoretic combines lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, with hydrochlorothiazide, a diuretic. It works by relaxing blood vessels and removing excess water and electrolytes from your body. Carvedilol, on the other hand, is a beta blocker that lowers blood pressure by relaxing blood vessels and slowing down your heart rate. Zestoretic is typically taken once daily, while carvedilol is taken twice daily in its immediate-release form or once daily in its extended-release form. Carvedilol is also used to manage heart failure and reduce the risk of death after a heart attack, whereas Zestoretic is primarily focused on lowering blood pressure. Common side effects of Zestoretic include dizziness, headache, and cough, while carvedilol can cause dizziness, tiredness, and diarrhea. Additionally, carvedilol should not be taken if you have asthma or certain heart conditions, whereas Zestoretic is not safe for use during pregnancy.
